Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2995848 | 0.97 | KMT2A (0.45) | KCNH2PLA2G2ANPC1RAB9AMEN1 | |
| SCHEMBL3008225 | 0.96 | PLA2G2A (0.45) | KCNH2PLA2G2ANPC1RAB9AMEN1 | |
| SCHEMBL2997974 | 0.95 | KCNH2 (0.44) | KCNH2PLA2G2ANPC1RAB9AMEN1 | |
| SCHEMBL2991509 | 0.95 | FAAH (0.48) | KCNH2PLA2G2ANPC1RAB9AMEN1 | |
| SCHEMBL3008455 | 0.94 | MEN1 (0.42) | KCNH2PLA2G2ANPC1RAB9AMEN1 | |
| SCHEMBL3006333 | 0.93 | MAPT (0.43) | KCNH2SMN1; SMN2RXFP1MAPTMAPK8 | |
| SCHEMBL3001465 | 0.92 | PLA2G2A (0.44) | KCNH2PLA2G2ANPC1RAB9AMEN1 | |
| SCHEMBL4090425 | 0.92 | CNR1 (0.42) | MEN1KMT2AFAAHSMN1; SMN2USP2 | |
| SCHEMBL3008127 | 0.91 | FAAH (0.44) | KCNH2PLA2G2ANPC1RAB9AMEN1 | |
| SCHEMBL3000373 | 0.91 | MAPT (0.43) | PLA2G2ANPC1RAB9AFAAHSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8884020-B2 | Indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| US-20100197708-A1 | INDOLE COMPOUNDS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2010-08-05 | — | — | US | disclosed |
| US-20090118503-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197708-A1 | INDOLE COMPOUNDS | IDO1, IDO2, TPH2 | KCNH2 2066/4885PLA2G2A 3285/4885NPC1 2681/4885 |
| US-20090118503-A1 | FAAH INHIBITORS | FAAH, FAAH2, CNR2 | KCNH2 1943/4885PLA2G2A 242/4885NPC1 2508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.