Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 2/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | ADK | P55263 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624415 | 0.88 | MKNK1 (0.50) | CNR2FYNMKNK1MKNK2MAPT | |
| SCHEMBL16672309 | 0.82 | ALDH1A1 (0.46) | ATRATRIPPIK3CDMAPTALDH1A1 | |
| SCHEMBL823332 | 0.76 | ALDH1A1 (0.48) | PIK3CDMAPTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL2558872 | 0.75 | DHFR (0.60) | FYNADKBTKPIK3CDPIK3CA | |
| SCHEMBL31455230 | 0.73 | AKT1 (0.56) | ATRATRIPMAPTMAPK1AKT1 | |
| SCHEMBL10094652 | 0.73 | GAA (0.55) | CNR2MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL28070394 | 0.72 | TTK (0.52) | CNR2FYNADKPIK3CDMAPT | |
| SCHEMBL10062975 | 0.72 | MAP4K4 (0.59) | MKNK1MKNK2MAPTKDM4ETDP1 | |
| SCHEMBL10094618 | 0.71 | CNR2 (0.58) | CNR2MAPTALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL623411 | 0.71 | MAP4K4 (0.61) | MKNK1MKNK2TNK2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226668-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |