Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.36 |
| ▸ | FEN1 | P39748 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17247583 | 1.00 | LMNA (0.41) | LMNASMN1; SMN2CYP2C19KDM4ENPSR1 | |
| SCHEMBL21746093 | 0.77 | LMNA (0.33) | LMNASMN1; SMN2CYP2C19KDM4ENPSR1 | |
| SCHEMBL17240013 | 0.76 | GAA (0.59) | LMNASMN1; SMN2KDM4ENPSR1KEAP1 | |
| SCHEMBL14223970 | 0.76 | KEAP1 (0.38) | LMNASMN1; SMN2CYP2C19KDM4ENPSR1 | |
| SCHEMBL17240100 | 0.76 | EDNRA (0.48) | LMNASMN1; SMN2CYP2C19KDM4ENPSR1 | |
| SCHEMBL10269008 | 0.72 | — | — | |
| SCHEMBL14842058 | 0.71 | HSD11B1 (0.49) | KDM4EKEAP1ALDH1A1HPGDHTT | |
| SCHEMBL13068149 | 0.71 | HTR6 (0.41) | LMNASMN1; SMN2CYP2C19KDM4ENPSR1 | |
| SCHEMBL7351894 | 0.71 | CA12 (0.46) | LMNASMN1; SMN2CYP2C19KDM4ECA12 | |
| SCHEMBL14645090 | 0.71 | ADRB3 (0.36) | LMNAKDM4ENPSR1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260211-B | Thiophene condensed ring derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-115260211-A | Thiophene fused ring containing derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-01 | — | — | CN | disclosed |