Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 5/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.37 |
| ▸ | VCP | P55072 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | KIT | P10721 | 4/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | LCK | P06239 | 3/20 | 0.36 |
| ▸ | CSF1R | P07333 | 3/20 | 0.36 |
| ▸ | PRKACA | P17612 | 3/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.36 |
| ▸ | PLK4 | O00444 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | LYN | P07948 | 2/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29967707 | 0.90 | MAPK10 (0.43) | MAPK8CDC7MAPK10KDRKIT | |
| SCHEMBL29967968 | 0.88 | MAPK10 (0.44) | MAPK8CDC7MAPK10KDRKIT | |
| SCHEMBL29967816 | 0.86 | PRMT6 (0.39) | MAPK8FGFR1MAPK10CSF1RMAPK9 | |
| SCHEMBL29967914 | 0.85 | AGTR2 (0.40) | MAPK8FGFR1PTGS2MAPK10KDR | |
| SCHEMBL29967841 | 0.85 | KDR (0.40) | FGFR1PTGS2KDRKITFLT3 | |
| SCHEMBL29969053 | 0.85 | PIM1 (0.41) | CSF1RGSK3BDYRK1ACLK4 | |
| SCHEMBL29968061 | 0.85 | MAPK8 (0.35) | MAPK8FGFR1MAPK10KDRKIT | |
| SCHEMBL29968100 | 0.84 | MAP2K1 (0.34) | MAPK8FGFR1PTGS2CDC7KDR | |
| SCHEMBL29967878 | 0.84 | MAPK10 (0.45) | MAPK8CDC7MAPK10KDRKIT | |
| SCHEMBL28871262 | 0.84 | MAPK10 (0.45) | MAPK8CDC7MAPK10KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260165-B | Benzo nitrogen-containing five-membered heterocyclic compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2024-08-06 | — | — | CN | disclosed |
| CN-115260165-A | Benzo nitrogen-containing five-membered heterocyclic compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2022-11-01 | — | — | CN | disclosed |