Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 11/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | BCR | P11274 | 3/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29967968 | 0.92 | MAPK10 (0.44) | MAPK10MAPK9MAPK8FLT3KIT | |
| SCHEMBL29967591 | 0.90 | MAPK8 (0.41) | MAPK10MAPK9MAPK8ABL1FLT3 | |
| SCHEMBL28871262 | 0.89 | MAPK10 (0.45) | MAPK10MAPK9MAPK8FLT3KIT | |
| SCHEMBL29967878 | 0.89 | MAPK10 (0.45) | MAPK10MAPK9MAPK8FLT3KIT | |
| SCHEMBL29967802 | 0.87 | FLT3 (0.43) | ABL1BCRFLT3KITCDC7 | |
| SCHEMBL29967841 | 0.86 | KDR (0.40) | ABL1BCRFLT3KITPLK4 | |
| SCHEMBL29968009 | 0.86 | EPHX2 (0.42) | ABL1BCRFLT3KITCDC7 | |
| SCHEMBL29967914 | 0.86 | AGTR2 (0.40) | MAPK10MAPK9MAPK8ABL1BCR | |
| SCHEMBL29968241 | 0.84 | ACMSD (0.36) | MAPK10MAPK9MAPK8ABL1BCR | |
| SCHEMBL29968331 | 0.84 | KDM4C (0.38) | MAPK10MAPK9MAPK8FLT3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260165-B | Benzo nitrogen-containing five-membered heterocyclic compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2024-08-06 | — | — | CN | disclosed |
| CN-115260165-A | Benzo nitrogen-containing five-membered heterocyclic compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2022-11-01 | — | — | CN | disclosed |