Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.51 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3872066 | 1.00 | JAK2 (0.51) | JAK2MAPK1PLK4DAPK3DYRK3 | |
| Hydrochloric Acid SCHEMBL27081766 | 0.99 | JAK2 (0.50) | JAK2MAPK1PLK4DAPK3DYRK3 | |
| SCHEMBL3571275 | 0.86 | RAB9A (0.57) | MAPK1ALDH1A1ALOX15MAPTKDM4E | |
| SCHEMBL1513343 | 0.86 | JAK2 (0.55) | JAK2JAK3POLBHPGD | |
| SCHEMBL2898350 | 0.83 | ALDH1A1 (0.47) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL29906783 | 0.83 | ALDH1A1 (0.47) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL28447448 | 0.83 | ACHE (0.39) | JAK2MAPK1PLK4DAPK3DYRK3 | |
| Hydrochloric Acid SCHEMBL29940234 | 0.82 | ALDH1A1 (0.46) | ALDH1A1CA12CA1CA2CA7 | |
| Hydrochloric Acid SCHEMBL3102567 | 0.82 | ALDH1A1 (0.46) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL30782284 | 0.82 | MAPK1 (0.57) | JAK2MAPK1PLK4DAPK3DYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313972-A1 | INDOLINE DERIVATIVES AS DDRS INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022200577-A1 | INDOLINE DERIVATIVES AS DDRS INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-09-29 | — | — | WO | disclosed |