Apigenin

Apigenin

SCHEMBL29968480

O=c1cc(-c2ccc(O)cc2)oc2cc(O)cc(O)c12.[Na]

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.97
CYP1B1 Q16678 7/20 0.97
ABCB1 P08183 6/20 0.97
MEN1 O00255 6/20 0.97
CYP3A4 P08684 6/20 0.97
MAPT P10636 6/20 0.97
CYP1A1 P04798 6/20 0.97
ALDH1A1 P00352 5/20 0.97
HPGD P15428 5/20 0.97
FTO Q9C0B1 5/20 0.97
CYP1A2 P05177 5/20 0.97
POLH Q9Y253 5/20 0.97
IP6K2 Q9UHH9 5/20 0.97
TP53 P04637 4/20 0.97
CYP2D6 P10635 4/20 0.97
CYP2C9 P11712 4/20 0.97
MAOA P21397 4/20 0.97
MAOB P27338 4/20 0.97
CYP2C19 P33261 4/20 0.97
SMN1; SMN2 Q16637 4/20 0.97

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Apigenin SCHEMBL5083245 0.98 KMT2A (1.00) KMT2ACYP1B1ABCB1MEN1CYP3A4
Apigenin SCHEMBL19428 0.98 KMT2A (1.00) KMT2ACYP1B1ABCB1MEN1CYP3A4
Apigenin SCHEMBL29351464 0.98 KMT2A (1.00) KMT2ACYP1B1ABCB1MEN1CYP3A4
Apigenin SCHEMBL29872582 0.97 KMT2A (0.97) KMT2ACYP1B1ABCB1MEN1CYP3A4
Apigenin SCHEMBL31168790 0.97 KMT2A (0.97) KMT2ACYP1B1ABCB1MEN1CYP3A4
Apigenin SCHEMBL1658882 0.97 KMT2A (0.97) KMT2ACYP1B1ABCB1MEN1CYP3A4
Apigenin SCHEMBL31477961 0.97 KMT2A (0.97) KMT2ACYP1B1ABCB1MEN1CYP3A4
Apigenin SCHEMBL29448148 0.97 KMT2A (0.97) KMT2ACYP1B1ABCB1MEN1CYP3A4
Apigenin SCHEMBL30544810 0.97 KMT2A (0.97) KMT2ACYP1B1ABCB1MEN1CYP3A4
Apigenin SCHEMBL29458838 0.97 KMT2A (0.97) KMT2ACYP1B1ABCB1MEN1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110478349-B Dressing for wound care and preparation method thereof 黑龙江中医药大学 2022-11-15 CN claimed
CN-110478349-B Dressing for wound care and preparation method thereof 黑龙江中医药大学 2022-11-15 CN disclosed
US-11491226-B2 Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compound TECHNOLOGY INVESTMENTS LC (US) 2022-11-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11491226-B2 Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compound ABCG2, CYP2F1, LSS KMT2A 3613/4885CYP1B1 26/4885ABCB1 62/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.