Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Apigenin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 6/20 | 0.97 |
| ▸ | FLT3 known ✓ | P36888 | 4/20 | 0.97 |
| ▸ | HDAC6 known ✓ | Q9UBN7 | 4/20 | 0.97 |
| ▸ | GSK3A known ✓ | P49840 | 3/20 | 0.97 |
| ▸ | GSK3B known ✓ | P49841 | 3/20 | 0.97 |
| ▸ | PARP1 known ✓ | P09874 | 3/20 | 0.97 |
| ▸ | PTGS2 known ✓ | P35354 | 2/20 | 0.97 |
| ▸ | THRB known ✓ | P10828 | 2/20 | 0.97 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.97 |
| ▸ | DPP4 known ✓ | P27487 | 2/20 | 0.97 |
| ▸ | SYK known ✓ | P43405 | 2/20 | 0.97 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.97 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.97 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.78 |
| ▸ | MMP7 known ✓ | P09237 | 1/20 | 0.76 |
| ▸ | ALOX5 known ✓ | P09917 | 1/20 | 0.76 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.76 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.76 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.70 |
| ▸ | PARP2 known ✓ | Q9UGN5 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Apigenin SCHEMBL1658882 | 1.00 | KMT2A (0.97) | KMT2ACYP1B1ABCB1MEN1CYP3A4 | |
| Apigenin SCHEMBL1655606 | 1.00 | KMT2A (0.97) | KMT2ACYP1B1ABCB1MEN1CYP3A4 | |
| Apigenin SCHEMBL29351464 | 0.98 | KMT2A (1.00) | KMT2ACYP1B1ABCB1MEN1CYP3A4 | |
| Apigenin SCHEMBL5083245 | 0.98 | KMT2A (1.00) | KMT2ACYP1B1ABCB1MEN1CYP3A4 | |
| Apigenin SCHEMBL19428 | 0.98 | KMT2A (1.00) | KMT2ACYP1B1ABCB1MEN1CYP3A4 | |
| Apigenin SCHEMBL31477961 | 0.97 | KMT2A (0.97) | KMT2ACYP1B1ABCB1MEN1CYP3A4 | |
| Apigenin SCHEMBL31168790 | 0.97 | KMT2A (0.97) | KMT2ACYP1B1ABCB1MEN1CYP3A4 | |
| Apigenin SCHEMBL29968480 | 0.97 | KMT2A (0.97) | KMT2ACYP1B1ABCB1MEN1CYP3A4 | |
| Apigenin SCHEMBL29448148 | 0.97 | KMT2A (0.97) | KMT2ACYP1B1ABCB1MEN1CYP3A4 | |
| Apigenin SCHEMBL29458838 | 0.97 | KMT2A (0.97) | KMT2ACYP1B1ABCB1MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2490679-B1 | METHODS OF MAKING AND USING COMPOSITIONS COMPRISING FLAVONOIDS | VIZURI HEALTH SCIENCES CONSUMER HEALTHCARE INC T/A VHS CONSUMER HEALTHCARE (US) | 2022-09-21 | — | — | EP | disclosed |