Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | CNR1 | P21554 | 3/20 | 0.54 |
| ▸ | CNR2 | P34972 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2070222 | 0.81 | MAPK1 (0.60) | ALDH1A1LMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1969935 | 0.79 | RAB9A (0.60) | ALDH1A1LMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14970878 | 0.76 | KDM4E (0.75) | ALDH1A1LMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10052386 | 0.76 | KDM4E (0.61) | ALDH1A1LMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5419386 | 0.75 | LMNA (0.52) | ALDH1A1LMNAKMT2ASMN1; SMN2GAA | |
| SCHEMBL1542696 | 0.75 | ALDH1A1 (0.67) | ALDH1A1LMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4429929 | 0.74 | ALDH1A1 (1.00) | ALDH1A1LMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5426961 | 0.74 | LMNA (0.53) | ALDH1A1LMNASMN1; SMN2GAARAB9A | |
| SCHEMBL11620052 | 0.73 | GAA (0.64) | ALDH1A1LMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4990548 | 0.73 | ALDH1A1 (0.50) | ALDH1A1LMNAKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173888-A1 | Nicotinamide Derivatives | PFIZER INC | 2010-07-08 | — | — | US | claimed |
| US-20100173888-A1 | Nicotinamide Derivatives | PFIZER INC | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173888-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | ALDH1A1 172/4885LMNA 1347/4885KMT2A 3206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.