Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19259879 | 0.82 | LOXL2 (0.39) | SMN1; SMN2ALDH1A1CYP1A2CYP2C19TSHR | |
| SCHEMBL29970758 | 0.76 | LOXL2 (0.43) | SMN1; SMN2RAB9AALDH1A1NPC1CYP1A2 | |
| SCHEMBL29970697 | 0.75 | LOXL2 (0.42) | SMN1; SMN2RAB9AALDH1A1NPC1CYP1A2 | |
| SCHEMBL19274461 | 0.75 | PDPK1 (0.44) | SMN1; SMN2RAB9ANPC1CYP1A2GAA | |
| SCHEMBL29971049 | 0.75 | PDPK1 (0.44) | SMN1; SMN2RAB9ANPC1CYP1A2GAA | |
| SCHEMBL28644286 | 0.74 | LOXL2 (0.41) | ALDH1A1CYP1A2CYP2C19KDM4EMAOA | |
| SCHEMBL29970081 | 0.74 | LOXL2 (0.43) | ALDH1A1TSHRGAALOXL2 | |
| SCHEMBL19260160 | 0.74 | LOXL2 (0.41) | SMN1; SMN2RAB9AALDH1A1NPC1CYP1A2 | |
| SCHEMBL19274640 | 0.71 | LOXL2 (0.40) | SMN1; SMN2ALDH1A1TSHRGAAL3MBTL1 | |
| SCHEMBL30699957 | 0.71 | LOXL2 (0.40) | SMN1; SMN2ALDH1A1TSHRGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220372028-A1 | Methylamine Derivatives as Lysysl Oxidase Inhibitors for the Treatment of Cancer | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2022-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220372028-A1 | Methylamine Derivatives as Lysysl Oxidase Inhibitors for the Treatment of Cancer | LOXL1, LOXL3, LOXL2 | SMN1; SMN2 3688/4885RAB9A 3478/4885ALDH1A1 2293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.