Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 6/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.33 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.32 |
| ▸ | SELE | P16581 | 4/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LOX | P28300 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28651627 | 0.87 | SIRT2 (0.43) | LOXL2SIRT2SIRT1SIRT3HTT | |
| SCHEMBL28663602 | 0.82 | SIRT2 (0.44) | LOXL2NTRK1SIRT2LOXL3SIRT1 | |
| SCHEMBL28644238 | 0.79 | LOXL2 (0.41) | LOXL2NTRK1LOXL3SIRT1ICAM1 | |
| SCHEMBL19259879 | 0.78 | LOXL2 (0.39) | LOXL2MAOANTRK1SIRT2LOXL3 | |
| SCHEMBL28657391 | 0.76 | LOXL2 (0.43) | LOXL2NTRK1SIRT2LOXL3SIRT1 | |
| SCHEMBL19274717 | 0.75 | PDPK1 (0.44) | LOXL2MAOACYP1A2 | |
| SCHEMBL28644194 | 0.74 | LOXL2 (0.42) | LOXL2NTRK1LOXL3HTTALDH1A1 | |
| SCHEMBL28643885 | 0.73 | LOXL3 (0.36) | LOXL2NTRK1LOXL3ICAM1SELE | |
| SCHEMBL28645865 | 0.72 | LOXL2 (0.40) | LOXL2NTRK1LOXL3ICAM1SELE | |
| SCHEMBL28651596 | 0.71 | ALDH1A1 (0.42) | LOXL2LOXL3ICAM1SELEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311839-B | Methylamine derivatives as lysyl oxidase inhibitors for the treatment of cancer | 癌症研究协会皇家癌症医院 | 2021-11-02 | — | — | CN | disclosed |