Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.70 |
| ▸ | RHEB | Q15382 | 6/20 | 0.62 |
| ▸ | EIF4A3 | P38919 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15515831 | 1.00 | GRIN1 (0.70) | GRIN1RHEBEIF4A3HPGDKDM4E | |
| SCHEMBL29063125 | 0.85 | GRIN1 (0.50) | GRIN1RHEBEIF4A3HPGDKDM4E | |
| SCHEMBL1144892 | 0.84 | EIF4A3 (0.63) | GRIN1RHEBEIF4A3HPGDKDM4E | |
| SCHEMBL29655546 | 0.84 | EIF4A3 (0.63) | GRIN1RHEBEIF4A3HPGDKDM4E | |
| SCHEMBL727389 | 0.82 | GRIN1 (1.00) | GRIN1RHEBEIF4A3HPGDKDM4E | |
| SCHEMBL29531428 | 0.82 | GRIN1 (1.00) | GRIN1RHEBEIF4A3HPGDKDM4E | |
| SCHEMBL24020677 | 0.81 | ULK1 (0.47) | GRIN1RHEBEIF4A3MEN1KMT2A | |
| SCHEMBL30310352 | 0.81 | ULK1 (0.47) | GRIN1RHEBEIF4A3MEN1KMT2A | |
| SCHEMBL21624049 | 0.79 | KDM4E (0.51) | GRIN1RHEBEIF4A3HPGDKDM4E | |
| SCHEMBL20505503 | 0.79 | EIF4A3 (0.54) | GRIN1RHEBEIF4A3HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976617-B1 | FUSED HETEROCYCLIC DERIVATIVES | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2025-04-23 | — | — | EP | disclosed |
| US-20220348592-A1 | FUSED HETEROCYCLIC DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2022-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220348592-A1 | FUSED HETEROCYCLIC DERIVATIVES | HAVCR2, HCCS, GOT2 | GRIN1 3749/4885RHEB 1262/4885EIF4A3 968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.