SCHEMBL29975671

SCHEMBL29975671

C[C@@H](NC(=O)c1ccc(NN)nc1)C(=O)N1CCC[C@H]1B(O)O

nearest known ligand 0.67

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ PREP P48147 15/20 0.67
▸ FAP Q12884 14/20 0.67
▸ DPP8 Q6V1X1 6/20 0.66
▸ DPP9 Q86TI2 5/20 0.66
▸ DPP4 P27487 9/20 0.46
▸ DPP7 Q9UHL4 8/20 0.46
▸ PITRM1 Q5JRX3 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29162847 1.00 PREP (0.67) PREPFAPDPP8DPP9DPP4
SCHEMBL23876857 1.00 PREP (0.67) PREPFAPDPP8DPP9DPP4
SCHEMBL25890297 0.85 PREP (0.77) PREPFAPDPP8DPP9DPP4
SCHEMBL25896315 0.85 FAP (0.61) PREPFAPDPP8DPP9DPP4
SCHEMBL25890341 0.82 PREP (0.79) PREPFAPDPP8DPP9DPP4
SCHEMBL29162866 0.81 FAP (0.49) PREPFAPDPP8DPP9DPP4
SCHEMBL30805672 0.81 FAP (0.49) PREPFAPDPP8DPP9DPP4
SCHEMBL25895634 0.81 PREP (0.56) PREPFAPDPP8DPP9DPP4
SCHEMBL29359250 0.80 PREP (1.00) PREPFAPDPP8DPP9DPP4
SCHEMBL25890370 0.79 FAP (0.74) PREPFAPDPP8DPP9DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4331624-A4 RADIOPHARMACEUTICALS BASED ON ((R)-1-((6-HYDRAZINYLNICOTINOYL)-D-ALANYL)PYRROLIDIN-2-YL)BORONIC ACID (HYNIC-IFAP) FOR DETECTING THE OVEREXPRESSION OF FIBROBLAST ACTIVATION PROTEIN INSTITUTO NAC DE INVESTIGACIONES NUCLEARES (MX) 2026-05-06 — — EP disclosed
US-20240216551-A1 RADIOPHARMACEUTICALS BASED ON ((R)-1-((6-HYDRAZINYLNICOTINOYL)-D-ALANYL)PYRROLIDIN-2-YL)BORONIC ACID (HYNIC-IFAP) FOR DETECTING THE OVEREXPRESSION OF FIBROBLAST ACTIVATION PROTEIN INSTITUTO NACIONAL DE INVESTIGACIONES NUCLEARES (MX) 2024-07-04 — — US disclosed
EP-4331624-A1 RADIOPHARMACEUTICALS BASED ON ((R)-1-((6-HYDRAZINYLNICOTINOYL)-D-ALANYL)PYRROLIDIN-2-YL)BORONIC ACID (HYNIC-IFAP) FOR DETECTING THE OVEREXPRESSION OF FIBROBLAST ACTIVATION PROTEIN Instituto Nacional de Investigaciones Nucleares (MX) 2024-03-06 — — EP disclosed
CN-117642188-A Radiopharmaceuticals based on ((R) -1- ((6-hydrazinonicotinyl) -D-alanyl) pyrrolidin-2-yl) boronic acid (HYNIC-IFAP) for detection of fibroblast activation protein overexpression 国家核研究所 2024-03-01 — — CN disclosed
WO-2022231410-A1 RADIOPHARMACEUTICALS BASED ON ((R)-1-((6-HYDRAZINYLNICOTINOYL)-D-ALANYL)PYRROLIDIN-2-YL)BORONIC ACID (HYNIC-IFAP) FOR DETECTING THE OVEREXPRESSION OF FIBROBLAST ACTIVATION PROTEIN INSTITUTO NACIONAL DE INVESTIGACIONES NUCLEARES (MX) 2022-11-03 — — WO disclosed
WO-2022231410-A1 RADIOPHARMACEUTICALS BASED ON ((R)-1-((6-HYDRAZINYLNICOTINOYL)-D-ALANYL)PYRROLIDIN-2-YL)BORONIC ACID (HYNIC-IFAP) FOR DETECTING THE OVEREXPRESSION OF FIBROBLAST ACTIVATION PROTEIN INSTITUTO NACIONAL DE INVESTIGACIONES NUCLEARES (MX) 2022-11-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240216551-A1 RADIOPHARMACEUTICALS BASED ON ((R)-1-((6-HYDRAZINYLNICOTINOYL)-D-ALANYL)PYRROLIDIN-2-YL)BORONIC ACID (HYNIC-IFAP) FOR DETECTING THE OVEREXPRESSION OF FIBROBLAST ACTIVATION PROTEIN FAP, FIBP, ENPEP PREP 88/4885FAP 1/4885DPP8 766/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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