Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 7/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | GAK | O14976 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29403274 | 0.81 | ALK (0.50) | PTGESALKNT5ESMN1; SMN2HTT | |
| SCHEMBL1809544 | 0.81 | ALK (0.50) | PTGESALKNT5ESMN1; SMN2HTT | |
| SCHEMBL17531614 | 0.72 | PDE4A (0.47) | SMN1; SMN2CYP1A2CYP2C19KDM4EMEN1 | |
| SCHEMBL19890459 | 0.72 | PTGES (0.46) | PTGESALKNT5ESMN1; SMN2HTT | |
| SCHEMBL31236169 | 0.69 | PDE4A (0.53) | ALKSMN1; SMN2HTTCYP1A2CYP2C19 | |
| SCHEMBL29531805 | 0.69 | NT5E (0.46) | PTGESALKNT5EHTTCYP1A2 | |
| SCHEMBL858150 | 0.69 | PDE4A (0.53) | ALKSMN1; SMN2HTTCYP1A2CYP2C19 | |
| SCHEMBL7699263 | 0.69 | NT5E (0.46) | PTGESALKNT5EHTTCYP1A2 | |
| SCHEMBL438932 | 0.69 | ACHE (0.46) | PTGESALKNT5EHTTPABPC1 | |
| SCHEMBL17075876 | 0.68 | NT5E (0.38) | PTGESALKNT5ESMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4329757-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022232331-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-11-03 | — | — | WO | disclosed |