Sugi Predict

Sugi Predict / Compounds / SCHEMBL17075876

SCHEMBL17075876

SCHEMBL17075876

Clc1cnnc2cc(Br)ccc12

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ NT5E P21589 1/20 0.38
▸ PTGES O14684 6/20 0.37
▸ HTT P42858 2/20 0.36
▸ PABPC1 P11940 1/20 0.35
▸ CYP1A2 P05177 2/20 0.35
▸ CYP2C19 P33261 2/20 0.35
▸ ALK Q9UM73 2/20 0.35
▸ CYP2D6 P10635 1/20 0.35
▸ CYP2C9 P11712 1/20 0.35
▸ RXFP1 Q9HBX9 1/20 0.35
▸ ACHE P22303 1/20 0.35
▸ NPM1 P06748 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ BACE1 P56817 1/20 0.33
▸ TNF P01375 1/20 0.32
▸ POLB P06746 1/20 0.32
▸ PDPK1 O15530 1/20 0.32
▸ JAK2 O60674 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30462865 1.00 NT5E (0.38) NT5EPTGESHTTPABPC1CYP1A2
SCHEMBL30950664 0.85 NT5E (0.49) NT5EHTTPABPC1CYP1A2CYP2C19
SCHEMBL29665280 0.85 NT5E (0.49) NT5EHTTPABPC1CYP1A2CYP2C19
SCHEMBL4297621 0.85 NT5E (0.49) NT5EHTTPABPC1CYP1A2CYP2C19
SCHEMBL15028830 0.80 NR4A2 (0.40) CYP1A2ACHEPOLB
Hydrochloric Acid SCHEMBL15010418 0.78 NR4A2 (0.39) CYP1A2ACHEPOLB
SCHEMBL24252437 0.77 PABPC1 (0.47) HTTPABPC1CYP1A2CYP2C19ACHE
SCHEMBL6099341 0.77 HSD17B10 (0.40) HTTSMN1; SMN2
SCHEMBL4398975 0.77 LMNA (0.42) CYP1A2CYP2C19ACHE
SCHEMBL30467783 0.77 PABPC1 (0.47) HTTPABPC1CYP1A2CYP2C19ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260070932-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON INC (US) 2026-03-12 — — US disclosed
US-12522619-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2026-01-13 — — US disclosed
US-12509474-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2025-12-30 — — US disclosed
EP-4463462-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF Annexon, Inc. (US) 2024-11-20 — — EP disclosed
CN-118715231-A Complement factor inhibitors and uses thereof 安尼艾克松股份有限公司 2024-09-27 — — CN disclosed
CN-118388416-A Synthesis method of 4-chloro-6-bromocinnoline 凯美克(上海)医药科技有限公司 2024-07-26 — — CN disclosed
US-20240116877-A1 KIT KINASE INHIBITORS AND METHODS OF USE THEREOF DECIPHERA PHARMACEUTICALS, LLC 2024-04-11 — — US disclosed
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2024-04-04 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
US-11814404-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2023-11-14 — — US disclosed
WO-2023137166-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. (US) 2023-07-20 — — WO disclosed
WO-2023137166-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. (US) 2023-07-20 — — WO disclosed
WO-2023107863-A1 HETEROCYCLIC COMPOUNDS AS KIT KINASE INHIBITORS DECIPHERA PHARMACEUTICALS, LLC (US) 2023-06-15 — — WO disclosed
CN-116261564-A Inhibitors of complement factors and uses thereof 安尼艾克松股份有限公司 2023-06-13 — — CN disclosed
EP-4185592-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF Annexon, Inc. (US) 2023-05-31 — — EP disclosed
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2022-02-17 — — US disclosed
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2022-02-17 — — US disclosed
US-20150259331-A1 PROTOZOAN PARASITE GROWTH INHIBITORS THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. 2015-09-17 — — US disclosed
US-20150259331-A1 PROTOZOAN PARASITE GROWTH INHIBITORS THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. 2015-09-17 — — US disclosed
US-20150259331-A1 PROTOZOAN PARASITE GROWTH INHIBITORS THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. 2015-09-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 NT5E 288/4885PTGES 920/4885HTT 1359/4885
US-20220048930-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 NT5E 288/4885PTGES 920/4885HTT 1359/4885
US-11814404-B2 Inhibitors of complement factors and uses thereof CFB, CFH, C9 NT5E 288/4885PTGES 920/4885HTT 1359/4885
US-20240116877-A1 KIT KINASE INHIBITORS AND METHODS OF USE THEREOF KIT, MAP3K19, DCK NT5E 870/4885PTGES 4545/4885HTT 3604/4885
US-12509474-B2 Inhibitors of complement factors and uses thereof SSB, UACA, CFH NT5E 370/4885PTGES 2902/4885HTT 1417/4885
US-20260070932-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFH, CFB, C5 NT5E 138/4885PTGES 1656/4885HTT 462/4885
US-20150259331-A1 PROTOZOAN PARASITE GROWTH INHIBITORS TPP1, MKI67, PIGO NT5E 3487/4885PTGES 340/4885HTT 3447/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.