SCHEMBL29977334

SCHEMBL29977334

Clc1nc2ccccc2c2c1ncn2Cc1cccc(Cn2cccn2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.42
MAOB P27338 9/20 0.40
HTR6 P50406 8/20 0.39
MAPK1 P28482 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
PDE4A P27815 1/20 0.39
PRKACA P17612 1/20 0.38
PRKACG P22612 1/20 0.38
PRKACB P22694 1/20 0.38
CYP11B1 P15538 1/20 0.37
CYP11B2 P19099 1/20 0.37
LMNA P02545 1/20 0.37
POLB P06746 1/20 0.37
HRH2 P25021 1/20 0.37
ADRA1D P25100 1/20 0.37
HTR2A P28223 1/20 0.37
ADORA2A P29274 1/20 0.37
ADRA1A P35348 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29977373 0.88 TLR7 (0.52) HTTPDE4ALMNAPOLBHRH2
SCHEMBL9601993 0.84 CYP11B1 (0.50) HTTMAPK1SMN1; SMN2PDE4ACYP11B1
SCHEMBL24733009 0.81 MAOB (0.48) MAOBHTR6MAPK1SMN1; SMN2MAPT
SCHEMBL29808930 0.81 MAOB (0.48) MAOBHTR6MAPK1SMN1; SMN2MAPT
SCHEMBL8114967 0.80 KDM4E (0.47) HTTMAPK1SMN1; SMN2PDE4ACYP11B1
SCHEMBL29977341 0.78 MC4R (0.47) MAOBHTR6MAPTLMNAPOLB
SCHEMBL29809072 0.76 L3MBTL1 (0.46) HTTMAOBHTR6MAPK1SMN1; SMN2
SCHEMBL29808989 0.76 HTT (0.43) HTTMAOBHTR6SMN1; SMN2PDE4A
SCHEMBL24732796 0.76 HTT (0.43) HTTMAOBHTR6SMN1; SMN2PDE4A
SCHEMBL28802666 0.75 TNF (0.41) PDE4ACYP11B1CYP11B2LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022161420-A1 CLASS OF HETEROAROMATIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF 上海翊石医药科技有限公司 2022-08-04 WO disclosed