Sugi Predict

Sugi Predict / Compounds / SCHEMBL299775

SCHEMBL299775

SCHEMBL299775

FC(F)(F)c1nnc(Br)s1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.54
▸ CA1 P00915 1/20 0.41
▸ CA2 P00918 1/20 0.41
▸ CA4 P22748 1/20 0.41
▸ CA5A P35218 1/20 0.41
▸ CA5B Q9Y2D0 1/20 0.41
▸ HTT P42858 7/20 0.39
▸ NPC1 O15118 6/20 0.39
▸ SMN1; SMN2 Q16637 5/20 0.39
▸ LMNA P02545 4/20 0.39
▸ MEN1 O00255 3/20 0.39
▸ KMT2A Q03164 3/20 0.39
▸ CASP3 P42574 1/20 0.39
▸ SENP8 Q96LD8 1/20 0.39
▸ SENP7 Q9BQF6 1/20 0.39
▸ SENP6 Q9GZR1 1/20 0.39
▸ POLB P06746 1/20 0.35
▸ MPI P34949 1/20 0.35
▸ RAB9A P51151 5/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31339479 0.82 ALDH1A1 (0.65) ALDH1A1CA1CA2CA4CA5A
SCHEMBL2351643 0.72 CA1 (0.41) ALDH1A1CA1CA2CA4CA5A
SCHEMBL5074604 0.70 ALDH1A1 (0.52) ALDH1A1CA1CA2CA4CA5A
SCHEMBL5077077 0.70 ALDH1A1 (0.52) ALDH1A1CA1CA2CA4CA5A
SCHEMBL7829285 0.70 ALDH1A1 (0.52) ALDH1A1CA1CA2CA4CA5A
SCHEMBL5077071 0.70 ALDH1A1 (0.52) ALDH1A1CA1CA2CA4CA5A
SCHEMBL2879537 0.70 ALDH1A1 (0.52) ALDH1A1CA1CA2CA4CA5A
SCHEMBL701494 0.70 ALDH1A1 (0.52) ALDH1A1CA1CA2CA4CA5A
SCHEMBL12340927 0.70 ALDH1A1 (0.52) ALDH1A1CA1CA2CA4CA5A
SCHEMBL3394308 0.70 ALDH1A1 (0.52) ALDH1A1CA1CA2CA4CA5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250388589-A1 TRICYCLIC HETEROCYCLIC DERIVATIVES, COMPOSITIONS AND USES THEREOF DANATLAS PHARMACEUTICALS CO LTD (CN) 2025-12-25 — — US disclosed
US-20250320196-A1 APOL1 INHIBITORS AND METHODS OF USES THEREOF MAZE THERAPEUTICS INC (US) 2025-10-16 — — US disclosed
CN-120004880-A Thiadiazole substituted compound, pharmaceutical composition and application thereof 上海璎黎药业有限公司 2025-05-16 — — CN disclosed
US-20250154142-A1 THIADIAZOLE-SUBSTITUTED COMPOUND, PHARMACEUTICAL COMPOSITIONS THEREOF, AND APPLICATIONS THEREOF SHANGHAI YINGLI PHARMACEUTICAL CO., LTD. (CN) 2025-05-15 — — US disclosed
WO-2025082231-A1 HETEROAROMATIC SULFONAMIDE STRUCTURAL COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF 上海璎黎药业有限公司 2025-04-24 — — WO disclosed
US-20250129021-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2025-04-24 — — US disclosed
WO-2025085848-A1 ANTIBACTERIAL COMPOUNDS ARREPATH, INC. (US) 2025-04-24 — — WO disclosed
CN-119859145-A Heteroaromatic sulfonamide structure compound, pharmaceutical composition and application thereof 上海璎黎药业有限公司 2025-04-22 — — CN disclosed
WO-2025064718-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2025-03-27 — — WO disclosed
WO-2025056017-A1 FUSED BICYCLIC HETEROARYLS AS PARG INHIBITORS AND USES THEREOF ZAI LAB (SHANGHAI) CO., LTD. (CN) 2025-03-20 — — WO disclosed
US-4137234-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-01-30 — — US disclosed
US-4137237-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-01-30 — — US disclosed
US-4097669-A FUNGICIDES, BACTERICIDES, INSECTICIDES, ARTHROPODICIDES BAYER AKTIENGESELLSCHAFT (DT) 1978-06-27 — — US disclosed
US-4070475-A THIOALKYL-, AMINOALKYL-, AND OXYALKYL- SUBSTITUTED GUANIDINES SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1978-01-24 — — US disclosed
US-4024271-A INHIBITORS OF HISTAMINE ACTIVITY SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-05-17 — — US disclosed
US-4022797-A PHARMACEUTICALS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-05-10 — — US disclosed
US-4018931-A INHIBITION OF H-2 HISTAMINE RECEPTORS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-04-19 — — US disclosed
US-3968226-A 3-Heterocyclic thiomethylcephalosporins as antibacterial agents SMITHKLINE CORPORATION (US) 1976-07-06 — — US disclosed
US-3950333-A HISTAMINE INHIBITORS, OXYALKYL, THIOALKYL, AMINOALKYL DERIVATIVES SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1976-04-13 — — US disclosed
US-3950353-A HISTAMINE INHIBITORS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1976-04-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250154142-A1 THIADIAZOLE-SUBSTITUTED COMPOUND, PHARMACEUTICAL COMPOSITIONS THEREOF, AND APPLICATIONS THEREOF PARG, CYP2C19, CYP3A5 ALDH1A1 1108/4885CA1 4482/4885CA2 3539/4885
US-20250320196-A1 APOL1 INHIBITORS AND METHODS OF USES THEREOF APOL1, APOB, LDLR ALDH1A1 1201/4885CA1 4869/4885CA2 4828/4885
US-20250129021-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS MYC, KRAS, NRAS ALDH1A1 2630/4885CA1 4801/4885CA2 3902/4885
US-20250388589-A1 TRICYCLIC HETEROCYCLIC DERIVATIVES, COMPOSITIONS AND USES THEREOF CYP4A11, CYP11B1, CYP2D6 ALDH1A1 1726/4885CA1 863/4885CA2 445/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.