Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 7/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.34 |
| ▸ | KDM1A | O60341 | 3/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15135998 | 1.00 | RORC (0.37) | RORCTRPV4MAP3K5CYP11B1CYP11B2 | |
| SCHEMBL15135934 | 0.81 | MAP3K5 (0.50) | MAP3K5MAP3K6 | |
| SCHEMBL29977906 | 0.81 | MAP3K5 (0.50) | MAP3K5MAP3K6 | |
| SCHEMBL22473938 | 0.78 | CYP11B1 (0.44) | TRPV4CYP11B1CYP11B2 | |
| SCHEMBL22473996 | 0.78 | TRPV4 (0.36) | TRPV4CYP11B1CYP11B2EGLN2PDE4A | |
| SCHEMBL21649328 | 0.77 | MAP3K5 (0.43) | MAP3K5 | |
| SCHEMBL21649339 | 0.69 | MAP3K5 (0.42) | MAP3K5CYP11B1CYP11B2EGLN2PDE4A | |
| SCHEMBL28383965 | 0.68 | — | — | |
| SCHEMBL21706202 | 0.68 | MAP3K5 (0.35) | MAP3K5 | |
| SCHEMBL23048746 | 0.68 | MAP3K5 (0.31) | MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115504986-B | Apoptosis signal regulating kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-111107848-B | Pharmaceutical composition containing amide derivatives, and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-115504986-A | Apoptosis signal regulating kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-109265443-B | Heterocyclic compounds as ASK inhibitors and uses thereof | 南京圣和药业股份有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-109456308-B | Heterocyclic compounds as ASK inhibitors and their use | 南京圣和药业股份有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-111094250-B | Apoptosis signal regulating kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-11-04 | — | — | CN | disclosed |