SCHEMBL29978258

SCHEMBL29978258

O=C(Nc1cccc(Cl)c1)N1CCc2sc(-c3noc(C(F)(F)F)n3)cc2C1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.52
RAB9A P51151 3/20 0.52
CASP3 P42574 1/20 0.52
SENP8 Q96LD8 1/20 0.52
SENP7 Q9BQF6 1/20 0.52
SENP6 Q9GZR1 1/20 0.52
HDAC4 P56524 3/20 0.44
HDAC6 Q9UBN7 2/20 0.44
HDAC1 Q13547 1/20 0.44
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
ALDH1A1 P00352 2/20 0.43
RECQL P46063 2/20 0.43
NPSR1 Q6W5P4 2/20 0.43
GPR142 Q7Z601 1/20 0.42
FAAH O00519 1/20 0.40
MAPT P10636 4/20 0.40
GAA P10253 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29978228 0.92 CYP3A4 (0.44) NPC1RAB9ACASP3SENP8SENP7
SCHEMBL29977881 0.91 MAPT (0.39) NPC1RAB9ACASP3SENP8SENP7
SCHEMBL29978205 0.91 HDAC4 (0.47) NPC1RAB9ACASP3SENP8SENP7
SCHEMBL29978321 0.91 MEN1 (0.47) NPC1RAB9ACASP3SENP8SENP7
SCHEMBL29978115 0.89 DGAT1 (0.40) NPC1RAB9ACASP3SENP8SENP7
SCHEMBL29978406 0.89 NPC1 (0.53) NPC1RAB9AHDAC6HDAC1MEN1
SCHEMBL29978684 0.87 HDAC4 (0.51) HDAC4HDAC6HDAC1MEN1KMT2A
SCHEMBL29978083 0.87 NPC1 (0.47) NPC1RAB9AHDAC4HDAC6HDAC1
SCHEMBL29978389 0.87 NAMPT (0.46) HDAC4HDAC6NPSR1MAPTKDM4E
SCHEMBL29978771 0.86 POLB (0.46) NPC1RAB9AHDAC4HDAC6HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022234470-A1 NOVEL FUSED HETEROCYCLIC COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI INDUSTRIES LTD. (IN) 2022-11-10 WO claimed
WO-2022234470-A1 NOVEL FUSED HETEROCYCLIC COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI PI INDUSTRIES LTD. (IN) 2022-11-10 WO disclosed