Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.52 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.53 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 14/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.52 |
| ▸ | CCKAR | P32238 | 3/20 | 0.49 |
| ▸ | CCKBR | P32239 | 3/20 | 0.49 |
| ▸ | CD40 | P25942 | 1/20 | 0.48 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31025663 | 0.91 | LNPEP (0.59) | LNPEPERAP2NAALAD2 | |
| SCHEMBL31710294 | 0.91 | LNPEP (0.59) | LNPEPERAP2NAALAD2 | |
| SCHEMBL29531748 | 0.91 | OPRD1 (0.53) | OPRD1OPRM1OPRK1 | |
| SCHEMBL29590452 | 0.91 | OPRM1 (0.55) | OPRD1OPRM1OPRK1 | |
| SCHEMBL31236825 | 0.90 | OPRD1 (0.60) | LNPEPERAP2OPRD1OPRM1OPRK1 | |
| SCHEMBL29376413 | 0.89 | TFPI (0.56) | OPRD1OPRM1OPRK1 | |
| SCHEMBL30973968 | 0.88 | OPRD1 (0.49) | LNPEPERAP2OPRD1OPRM1OPRK1 | |
| SCHEMBL31236824 | 0.88 | LNPEP (0.62) | LNPEPERAP2OPRD1OPRM1OPRK1 | |
| SCHEMBL30973964 | 0.88 | OPRD1 (0.54) | LNPEPERAP2OPRD1OPRM1OPRK1 | |
| SCHEMBL30273402 | 0.87 | OPRD1 (0.53) | OPRD1OPRM1OPRK1CCKARCCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118871122-A | Chaperones as autophagy receptors for clearing protein aggregates and/or aggregation-prone proteins | 清华大学 | 2024-10-29 | — | — | CN | disclosed |
| CN-116963608-A | Method for selectively promoting animal welfare by modulating microbiota | 帝斯曼知识产权资产管理有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116847872-A | Method for reducing pathogenic E.coli by intervention with a selective feed additive comprising an enzyme such as a muramidase | 帝斯曼知识产权资产管理有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-115397448-A | Delivery of sialidases to cancer cells, immune cells and tumor microenvironment | 安迅生物制药公司 | 2022-11-25 | — | — | CN | disclosed |
| CN-115335530-A | Submerged fermentation method | 诺维信公司 | 2022-11-11 | — | — | CN | disclosed |
| CN-115297874-A | Immune cell delivery of sialidases to cancer cells, immune cells and tumor microenvironment | 安迅生物制药公司 | 2022-11-04 | — | — | CN | disclosed |