Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.41 |
| ▸ | TRAP1 | Q12931 | 8/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24814392 | 1.00 | DPP8 (0.41) | DPP8DPP9DPP7TRAP1NAMPT | |
| SCHEMBL24815669 | 0.86 | SMN1; SMN2 (0.42) | NAMPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL29986905 | 0.86 | SMN1; SMN2 (0.42) | NAMPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL24814740 | 0.84 | NLRP3 (0.35) | DPP8DPP9NAMPTSMN1; SMN2NPC1 | |
| SCHEMBL24817122 | 0.80 | NAMPT (0.44) | DPP8DPP9DPP7NAMPT | |
| SCHEMBL29987237 | 0.78 | SMN1; SMN2 (0.53) | DPP8DPP9DPP7TRAP1HSP90B1 | |
| SCHEMBL24814455 | 0.78 | SMN1; SMN2 (0.53) | DPP8DPP9DPP7TRAP1HSP90B1 | |
| SCHEMBL24815670 | 0.77 | NLRP3 (0.35) | MAPTLMNAALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL24814436 | 0.77 | DPP8 (0.42) | DPP8DPP9DPP7TRAP1NAMPT | |
| SCHEMBL29986713 | 0.77 | DPP8 (0.42) | DPP8DPP9DPP7TRAP1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022251343-A2 | CDGSH IRON SULFUR DOMAIN 2 ACTIVATORS AND USE THEREOF | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2022-12-01 | — | — | WO | disclosed |