Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL599554 | 0.93 | ALDH1A1 (0.42) | HCAR2ALDH1A1ALOX15RECQLHSD17B10 | |
| SCHEMBL7771328 | 0.93 | ALDH1A1 (0.42) | HCAR2ALDH1A1ALOX15RECQLHSD17B10 | |
| SCHEMBL599552 | 0.93 | ALDH1A1 (0.42) | HCAR2ALDH1A1ALOX15RECQLHSD17B10 | |
| Monomethyl Fumarate SCHEMBL28276520 | 0.77 | HCAR2 (0.68) | HCAR2ALDH1A1ALOX15RECQLHSD17B10 | |
| Monomethyl Fumarate SCHEMBL29562720 | 0.77 | HCAR2 (0.68) | HCAR2ALDH1A1ALOX15RECQLHSD17B10 | |
| Acetic Acid SCHEMBL27317270 | 0.76 | ALDH1A1 (0.40) | HCAR2ALDH1A1EGLN1KDM4EMAPT | |
| SCHEMBL26664497 | 0.76 | ALDH1A1 (0.48) | HCAR2ALDH1A1ALOX15RECQLHSD17B10 | |
| SCHEMBL1905112 | 0.76 | ALDH1A1 (0.48) | HCAR2ALDH1A1ALOX15RECQLHSD17B10 | |
| SCHEMBL7037263 | 0.75 | ALDH1A1 (0.43) | HCAR2ALDH1A1EGLN1KDM4EMAPT | |
| Maleic Acid SCHEMBL30781489 | 0.75 | TSHR (0.50) | HCAR2ALDH1A1ALOX15RECQLHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022250058-A1 | NITRILE GROUP-CONTAINING COPOLYMER RUBBER, RUBBER COMPOSITION, AND CROSSLINKED RUBBER | 日本ゼオン株式会社 | 2022-12-01 | — | — | WO | disclosed |
| WO-2022210392-A1 | RUBBER LAMINATE AND HOSE | 日本ゼオン株式会社 | 2022-10-06 | — | — | WO | disclosed |