Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 3/20 | 0.33 |
| ▸ | PIM1 | P11309 | 9/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 2/20 | 0.30 |
| ▸ | CLK3 | P49761 | 2/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.30 |
| ▸ | SGK1 | O00141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL760626 | 1.00 | SSTR4 (0.33) | SSTR4PIM1PIM2GPR119PTPN11 | |
| SCHEMBL760625 | 1.00 | SSTR4 (0.33) | SSTR4PIM1PIM2GPR119PTPN11 | |
| SCHEMBL290047 | 0.80 | GPR119 (0.36) | GPR119 | |
| SCHEMBL300080 | 0.80 | GPR119 (0.36) | GPR119 | |
| SCHEMBL3512362 | 0.80 | GPR119 (0.36) | GPR119 | |
| SCHEMBL757014 | 0.80 | GPR119 (0.36) | GPR119 | |
| SCHEMBL756592 | 0.77 | GPR119 (0.44) | GPR119 | |
| SCHEMBL756593 | 0.77 | GPR119 (0.44) | GPR119 | |
| SCHEMBL288817 | 0.77 | GPR119 (0.41) | GPR119PTPN11KCNH2 | |
| SCHEMBL759311 | 0.77 | GPR119 (0.41) | GPR119PTPN11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427450-A1 | GPR 119 MODULATORS | Pfizer Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| EP-2427448-A1 | Gpr 119 modulators | Pfizer Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128414-A1 | GPR 119 MODULATORS | PFIZER INC. (US) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010128425-A1 | GPR 119 MODULATORS | PFIZER INC. (US) | 2010-11-11 | — | — | WO | disclosed |