Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.64 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.58 |
| ▸ | TUBB | P07437 | 1/20 | 0.58 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.58 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.58 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.58 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.58 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.58 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.58 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.58 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.58 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.58 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.58 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.58 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.58 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380867 | 0.92 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL3004931 | 0.90 | TUBB4A (0.56) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL3008415 | 0.89 | TUBB4A (0.71) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL3007985 | 0.89 | TUBB4A (0.57) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL3007381 | 0.87 | TUBB4A (0.52) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL3005134 | 0.85 | TUBB4A (0.55) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL3004023 | 0.85 | TUBB4A (0.57) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL3001773 | 0.84 | TUBB4A (0.52) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL4083410 | 0.84 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DTUBB4A | |
| SCHEMBL3000335 | 0.84 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DTUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118503-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. | 2009-05-07 | — | — | US | claimed |
| US-8884020-B2 | Indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| US-20100197708-A1 | INDOLE COMPOUNDS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2010-08-05 | — | — | US | disclosed |
| US-20090118503-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197708-A1 | INDOLE COMPOUNDS | IDO1, IDO2, TPH2 | PDE4A 1448/4885PDE4B 1689/4885PDE4C 2350/4885 |
| US-20090118503-A1 | FAAH INHIBITORS | FAAH, FAAH2, CNR2 | PDE4A 625/4885PDE4B 664/4885PDE4C 1114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.