Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24706908 | 1.00 | ASIC3 (0.35) | ASIC3NOS3NOS1NOS2NUDT1 | |
| SCHEMBL30573717 | 0.78 | PRKCI (0.44) | ASIC3NOS3NOS1NOS2KDM4E | |
| SCHEMBL3992526 | 0.78 | PRKCI (0.44) | ASIC3NOS3NOS1NOS2KDM4E | |
| SCHEMBL20299141 | 0.78 | KDM4E (0.35) | KDM4E | |
| SCHEMBL15102663 | 0.75 | ASIC3 (0.38) | ASIC3NOS3NOS1NOS2KDM4E | |
| SCHEMBL30505883 | 0.75 | LOXL2 (0.40) | ASIC3NOS3NOS1NOS2KDM4E | |
| SCHEMBL16094673 | 0.75 | LOXL2 (0.40) | ASIC3NOS3NOS1NOS2KDM4E | |
| SCHEMBL23916448 | 0.74 | ENPP2 (0.33) | — | |
| Hydrochloric Acid SCHEMBL28398282 | 0.73 | ASIC3 (0.37) | ASIC3NOS3NOS1NOS2KDM4E | |
| SCHEMBL24706940 | 0.72 | LOXL2 (0.30) | LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347032-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117813302-A | Substituted tetrahydrofuran-2-carboxamides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| WO-2022256702-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-12-08 | — | — | WO | disclosed |