Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2995539 | 0.84 | ALDH1A1 (0.47) | ALDH1A1PTPN1KEAP1NFE2L2MTNR1A | |
| SCHEMBL4956387 | 0.77 | ALDH1A1 (0.53) | ALDH1A1PTPN1KEAP1NFE2L2MTNR1A | |
| SCHEMBL646518 | 0.76 | ALDH1A1 (0.54) | ALDH1A1PTPN1KEAP1NFE2L2 | |
| SCHEMBL13523864 | 0.75 | MTNR1A (0.74) | MTNR1AMTNR1B | |
| SCHEMBL13523859 | 0.74 | MAOB (0.52) | MTNR1AFLT3APPMTNR1BMMP13 | |
| SCHEMBL3917977 | 0.74 | KEAP1 (0.50) | ALDH1A1PTPN1KEAP1NFE2L2 | |
| SCHEMBL22412494 | 0.74 | KEAP1 (0.52) | KEAP1NFE2L2 | |
| SCHEMBL1731363 | 0.73 | GAA (0.53) | ALDH1A1KEAP1NFE2L2 | |
| SCHEMBL13523866 | 0.72 | TRPM8 (0.53) | MTNR1AMAOB | |
| SCHEMBL3918404 | 0.72 | ALDH1A1 (0.52) | ALDH1A1PTPN1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100197744-A1 | Organic Compounds | BARNES DAVID | 2010-08-05 | — | — | US | disclosed |
| EP-2155704-A1 | THIADIAZOLE DERIVATIVES AS ANTIDIABETIC AGENTS | Novartis Ag (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008148744-A1 | THIADIAZOLE DERIVATIVES AS ANTIDIABETIC AGENTS | NOVARTIS AG (CH) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197744-A1 | Organic Compounds | PTPRS, PTPRO, PTPRC | ALDH1A1 3001/4885PTPN1 25/4885KEAP1 1378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.