SCHEMBL30003719

SCHEMBL30003719

C#CCCC(=O)NCCCC[C@H](NC(=O)CCC#C)C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NOD1 Q9Y239 3/20 0.48
FOLH1 Q04609 2/20 0.46
ALB P02768 3/20 0.45
GLP1R P43220 8/20 0.43
GNPAT O15228 1/20 0.43
EPHX2 P34913 1/20 0.42
FNTA P49354 1/20 0.40
FNTB P49356 1/20 0.40
PGGT1B P53609 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18496714 0.88 FOLH1 (0.64) FOLH1
SCHEMBL18516883 0.88 FOLH1 (0.64) FOLH1
SCHEMBL18516882 0.88 FOLH1 (0.64) FOLH1
SCHEMBL1564794 0.87 ALDH1A1 (0.45) NOD1FOLH1ALBGNPATEPHX2
SCHEMBL30003706 0.86 GLP1R (0.42) NOD1GLP1R
SCHEMBL22994976 0.84 MEN1 (0.51) NOD1FOLH1
SCHEMBL867922 0.84 CAPN1 (0.47) FOLH1ALB
SCHEMBL867921 0.84 CAPN1 (0.47) FOLH1ALB
SCHEMBL19358763 0.84 MEN1 (0.51) NOD1FOLH1
SCHEMBL19358764 0.84 MEN1 (0.51) NOD1FOLH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11866518-B2 Bicyclic peptide ligands specific for TSLP BICYCLETX LIMITED (GB) 2024-01-09 US disclosed
EP-4132481-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TSLP BicycleTX Limited (GB) 2023-02-15 EP disclosed
US-20220363718-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TSLP BICYCLETX LIMITED (GB) 2022-11-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220363718-A1 BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR TSLP TSLP, VIP, CCL2 NOD1 744/4885FOLH1 1591/4885ALB 2369/4885
US-11866518-B2 Bicyclic peptide ligands specific for TSLP TSLP, VIP, CCL2 NOD1 744/4885FOLH1 1591/4885ALB 2369/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.