Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 1/20 | 0.59 |
| ▸ | PTGES | O14684 | 2/20 | 0.56 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | TYMP | P19971 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19583424 | 0.78 | PTGES (0.78) | MITFPTGESALOX5ALDH1A1SMN1; SMN2 | |
| SCHEMBL295233 | 0.75 | PTGES (0.56) | MITFPTGESELANEALOX5ALDH1A1 | |
| SCHEMBL28549436 | 0.75 | PTGES (0.56) | MITFPTGESALOX5ALDH1A1SMN1; SMN2 | |
| SCHEMBL295232 | 0.75 | PTGES (0.56) | MITFPTGESELANEALOX5ALDH1A1 | |
| SCHEMBL1649762 | 0.75 | PTGES (0.56) | MITFPTGESALOX5ALDH1A1SMN1; SMN2 | |
| SCHEMBL31661103 | 0.75 | PTGES (0.56) | MITFPTGESALOX5ALDH1A1SMN1; SMN2 | |
| SCHEMBL6449120 | 0.75 | PTGES (0.56) | MITFPTGESELANEALOX5ALDH1A1 | |
| SCHEMBL31604207 | 0.75 | PTGES (0.56) | MITFPTGESELANEALOX5ALDH1A1 | |
| SCHEMBL21058262 | 0.75 | PTGES (0.56) | MITFPTGESALOX5ALDH1A1SMN1; SMN2 | |
| SCHEMBL12958021 | 0.75 | ELANE (0.50) | ELANEALDH1A1HPGDKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120225873-A1 | COMPOUNDS FOR ALZHEIMER'S DISEASE | MYREXIS, INC. (US) | 2012-09-06 | — | — | US | claimed |
| CN-119613320-A | Synthesis method of compound 3-iodo-1H-indole-2-carboxylic acid | 上海毕臣生化科技有限公司 | 2025-03-14 | — | — | CN | disclosed |
| EP-2970118-B1 | COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | MANFREDI JOHN (US) | 2018-09-12 | — | — | EP | disclosed |
| EP-2813498-B1 | Compounds for Alzheimer's disease | MANFREDI JOHN (US) | 2016-04-20 | — | — | EP | disclosed |
| CN-103221397-B | Novel compositions and methods for controlling nematode pests | MONSANTO TECHNOLOGY LLC (US) | 2016-04-13 | — | — | CN | disclosed |
| EP-2970118-A1 | COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | Manfredi, John (US) | 2016-01-20 | — | — | EP | disclosed |
| US-9216966-B2 | Compounds for Alzheimer's disease | Manfredi, John (US) | 2015-12-22 | — | — | US | disclosed |
| CN-104768931-A | Compounds and therapeutic uses thereof | ALZHEIMER S INST OF AMERICA INC | 2015-07-08 | — | — | CN | disclosed |
| CN-103370316-B | 3-aryl-6-aryl- [1,2,4] triazolo [4,3-a ] pyridines as cell proliferation inhibitors and uses thereof | IMPACT THERAPEUTICS INC | 2015-06-24 | — | — | CN | disclosed |
| US-9034871-B2 | Compounds for Alzheimer's disease | Manfredi, John (US) | 2015-05-19 | — | — | US | disclosed |
| CN-1176941-C | Caspase inhibitors and the use thereof | ά | 2004-11-24 | — | — | CN | disclosed |
| CN-1516700-A | Substituted 4H-chromenes and analogs as activators ofgasp ases and inducers of apoptosis and use thereof | ά | 2004-07-28 | — | — | CN | disclosed |
| CN-1382119-A | Substituted alpha-hydroxy acid caspase inhibitors and uses thereof | CYTOVIA INC (US) | 2002-11-27 | — | — | CN | disclosed |
| CN-1379785-A | Caspase inhibitors for the treatment and prevention of chemotherapy and radiotherapy induced cell death | CYTOVIA INC (US) | 2002-11-13 | — | — | CN | disclosed |
| CN-1360591-A | 3 alpha-hydroxy-3 beta-methoxymethyl-21-heterocyclic substituted steroids having anesthetic activity | PIDU PHARMACEUTICAL INC (US) | 2002-07-24 | — | — | CN | disclosed |
| CN-1349496-A | Caspase inhibitors and uses thereof | CYTOVIA INC (US) | 2002-05-15 | — | — | CN | disclosed |
| CN-1346344-A | Substituted 2-aminobenzamide caspase ihibitors and the use thereof | CYTOVIA INC (US) | 2002-04-24 | — | — | CN | disclosed |
| US-5324648-A | Anticoagulants; antitumor agents | GEORGIA TECH RESEARCH CORPORATION (US) | 1994-06-28 | — | — | US | disclosed |
| US-4954519-A | Isocoumarins with basic substituents as serine proteases inhibitors, anticoagulants and anti-inflammatory agents | GEORGIA TECH RESEARCH CORPORATION (US) | 1990-09-04 | — | — | US | disclosed |
| US-4845242-A | ANTITUMOR | GEORGIA TECH RESEARCH CORPORATION (US) | 1989-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225873-A1 | COMPOUNDS FOR ALZHEIMER'S DISEASE | PSEN2, CHAT, PSEN1 | MITF 4590/4885PTGES 3226/4885ELANE 4785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.