Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | TYMP | P19971 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | C1R | P00736 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | C1S | P09871 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31661103 | 1.00 | PTGES (0.56) | PTGESMITFALOX5ALDH1A1HPGD | |
| SCHEMBL19583424 | 0.78 | PTGES (0.78) | PTGESMITFALOX5ALDH1A1HPGD | |
| SCHEMBL295232 | 0.75 | PTGES (0.56) | PTGESMITFALOX5ALDH1A1HPGD | |
| SCHEMBL6449120 | 0.75 | PTGES (0.56) | PTGESMITFALOX5ALDH1A1HPGD | |
| SCHEMBL295233 | 0.75 | PTGES (0.56) | PTGESMITFALOX5ALDH1A1HPGD | |
| SCHEMBL28549436 | 0.75 | PTGES (0.56) | PTGESMITFALOX5ALDH1A1HPGD | |
| SCHEMBL3000739 | 0.75 | MITF (0.59) | PTGESMITFALOX5ALDH1A1HPGD | |
| SCHEMBL1649762 | 0.75 | PTGES (0.56) | PTGESMITFALOX5ALDH1A1HPGD | |
| SCHEMBL31604207 | 0.75 | PTGES (0.56) | PTGESMITFALOX5ALDH1A1HPGD | |
| SCHEMBL31179834 | 0.75 | MAPT (0.58) | PTGESMITFALOX5ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10865163-B2 | Carbon dioxide as a directing group for C—H functionalization reactions involving Lewis basic amines, alcohols, thiols, and phosphines for the synthesis of compounds | THE UNIVERSITY OF TOLEDO (US) | 2020-12-15 | — | — | US | claimed |
| US-20190185392-A1 | Carbon Dioxide as a Directing Group for C-H Functionalization Reactions Involving Lewis Basic Amines, Alcohols, Thiols, and Phosphines for the Synthesis of Compounds | THE UNIVERSITY OF TOLEDO (US) | 2019-06-20 | — | — | US | claimed |
| CN-109251192-B | Preparation method of 3-position or 4-position trifluoromethyl substituted isocoumarin | 江西师范大学 | 2022-03-04 | — | — | CN | disclosed |
| US-10865163-B2 | Carbon dioxide as a directing group for C—H functionalization reactions involving Lewis basic amines, alcohols, thiols, and phosphines for the synthesis of compounds | THE UNIVERSITY OF TOLEDO (US) | 2020-12-15 | — | — | US | disclosed |
| US-20190185392-A1 | Carbon Dioxide as a Directing Group for C-H Functionalization Reactions Involving Lewis Basic Amines, Alcohols, Thiols, and Phosphines for the Synthesis of Compounds | THE UNIVERSITY OF TOLEDO (US) | 2019-06-20 | — | — | US | disclosed |
| CN-109251192-A | 3 or 4 position trifluoromethyls replace the preparation method of isocoumarin | 江西师范大学 | 2019-01-22 | — | — | CN | disclosed |
| CN-108623573-A | Isocoumarin derivative and synthetic method thereof | 河北农业大学 | 2018-10-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190185392-A1 | Carbon Dioxide as a Directing Group for C-H Functionalization Reactions Involving Lewis Basic Amines, Alcohols, Thiols, and Phosphines for the Synthesis of Compounds | CHKB, HRH3, PNMT | PTGES 1283/4885MITF 4350/4885ALOX5 780/4885 |
| US-10865163-B2 | Carbon dioxide as a directing group for C—H functionalization reactions involving Lewis basic amines, alcohols, thiols, and phosphines for the synthesis of compounds | CHKB, HRH3, PNMT | PTGES 1344/4885MITF 4314/4885ALOX5 821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.