Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 3/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300407 | 0.86 | NTRK1 (0.40) | AXLDYRK1ARIPK1KITGSK3B | |
| SCHEMBL15154912 | 0.74 | SMN1; SMN2 (0.44) | DYRK1ADYRK1BMETLMNAPOLB | |
| SCHEMBL1713774 | 0.71 | KMT2A (0.51) | AXLKMT2AALDH1A1CCNT1CDK9 | |
| SCHEMBL300130 | 0.69 | MTNR1A (0.43) | AXLDYRK1ADYRK1BRIPK1KIT | |
| SCHEMBL4716579 | 0.66 | POLB (0.57) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL25785930 | 0.66 | AXL (0.71) | AXLDYRK1ACDK8TNIKCDK5 | |
| SCHEMBL29953854 | 0.64 | KMT2A (0.46) | AXLERN1DYRK1ADYRK1BRIPK1 | |
| SCHEMBL4355680 | 0.64 | KMT2A (0.46) | AXLERN1DYRK1ADYRK1BRIPK1 | |
| SCHEMBL29954974 | 0.64 | AXL (0.39) | AXLDYRK1ADYRK1BKMT2AMET | |
| SCHEMBL25786059 | 0.64 | AXL (0.41) | AXLDYRK1ARIPK1KMT2AMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427433-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | Plexxikon, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |