Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.40 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 4/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | MARK3 | P27448 | 2/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.38 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | BLK | P51451 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300124 | 0.86 | AXL (0.39) | KITAXLDYRK1AGSK3BCDK5 | |
| SCHEMBL300130 | 0.83 | MTNR1A (0.43) | NTRK1NEK1KITAXLDYRK1A | |
| SCHEMBL1713918 | 0.73 | ALDH1A1 (0.55) | NTRK1NEK1KITDYRK1ACSF1R | |
| SCHEMBL27530428 | 0.70 | ERN1 (0.49) | CYP19A1 | |
| SCHEMBL8141976 | 0.69 | MTNR1A (0.44) | DYRK1ASYKEGFRMTNR1AMTNR1B | |
| SCHEMBL31451378 | 0.69 | MTNR1A (0.44) | DYRK1ASYKEGFRMTNR1AMTNR1B | |
| SCHEMBL1716453 | 0.69 | POLB (0.53) | CYP19A1MTNR1AMTNR1B | |
| SCHEMBL300129 | 0.67 | MAOB (0.49) | — | |
| SCHEMBL10638535 | 0.67 | MEN1 (0.45) | CYP19A1 | |
| SCHEMBL298453 | 0.66 | AAK1 (0.49) | NEK1AXLIRAK4MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427433-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | Plexxikon, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |