Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1456892 | 0.82 | HCAR2 (0.41) | TDP1PARP1IDO1ALDH1A1PRKCI | |
| SCHEMBL3753128 | 0.79 | PRKCI (0.47) | BRD4METTDP1BLMGAA | |
| SCHEMBL918364 | 0.75 | SCN4A (0.52) | METPARP1ALDH1A1HPGDSSCN4A | |
| Hydrochloric Acid SCHEMBL30014721 | 0.73 | SCN4A (0.50) | METPARP1ALDH1A1HPGDSSCN4A | |
| SCHEMBL6538305 | 0.72 | ITK (0.48) | ABL1PARP1AURKA | |
| SCHEMBL4787445 | 0.72 | SCN4A (0.48) | MEN1KMT2APARP1ALDH1A1HPGDS | |
| SCHEMBL11094847 | 0.71 | PDPK1 (0.52) | MEN1THRBBLMKMT2AALDH1A1 | |
| SCHEMBL1710995 | 0.71 | NPC1 (0.45) | BRD4METTDP1TDP2NSD2 | |
| SCHEMBL4732940 | 0.71 | CSNK1A1 (0.42) | BRD4MEN1KMT2AIDO1ALDH1A1 | |
| SCHEMBL20744330 | 0.71 | PDE4B (0.40) | BRD4METGAAPARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9403799-B2 | Pyrimidinyl-pyridazinone derivatives for treating a disease which is influenced by inhibition of met kinase | MERCK PATENT GMBH (DE) | 2016-08-02 | — | — | US | disclosed |
| US-20160067241-A1 | COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED NAPHTHALIMIDES SUCH AS AMONAFIDE FOR THE TREATMENT OF IMMUNOLOGICAL, METABOLIC, INFECTIOUS, AND BENIGN OR NEOPLASTIC HYPERPROLIFERATIVE DISEASE CONDITIONS | BROWN DENNIS M (US) | 2016-03-10 | — | — | US | disclosed |
| US-9062029-B2 | Pyrimidinyl pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2015-06-23 | — | — | US | disclosed |
| WO-2014179528-A2 | COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED NAPHTHALIMIDES SUCH AS AMONAFIDE FOR THE TREATMENT OF IMMUNOLOGICAL, METABOLIC, INFECTIOUS, AND BENIGN OR NEOPLASTIC HYPERPROLIFERATIVE DISEASE CONDITIONS | BROWN DENNIS M (US) | 2014-11-06 | — | — | WO | disclosed |
| US-8658643-B2 | Pyrimidinyl pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2014-02-25 | — | — | US | disclosed |
| US-8329692-B2 | Pyrimidinyl pyridazinone derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-12-11 | — | — | US | disclosed |
| US-20100197690-A1 | Pyrimidinyl Pyridazinone Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160067241-A1 | COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED NAPHTHALIMIDES SUCH AS AMONAFIDE FOR THE TREATMENT OF IMMUNOLOGICAL, METABOLIC, INFECTIOUS, AND BENIGN OR NEOPLASTIC HYPERPROLIFERATIVE DISEASE CONDITIONS | MYC, NME2, TP53 | BRD4 1534/4885MET 592/4885TDP1 1628/4885 |
| US-20100197690-A1 | Pyrimidinyl Pyridazinone Derivatives | MET, MERTK, ABL1 | BRD4 826/4885MET 1/4885TDP1 2225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.