Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A2 | P31639 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442750 | 0.80 | BCL2 (0.54) | CYP3A4CYP2D6CYP2C19TSHRBCL2 | |
| SCHEMBL9066731 | 0.77 | BCL2 (0.50) | CYP3A4CYP2D6CYP2C19TSHRBCL2 | |
| SCHEMBL3301748 | 0.75 | CYP3A4 (0.53) | CYP3A4CYP2D6CYP2C19TSHRBCL2 | |
| SCHEMBL1276089 | 0.75 | CYP3A4 (0.57) | CYP3A4CYP2D6CYP2C19TSHRBCL2 | |
| SCHEMBL607838 | 0.74 | BCL2 (0.47) | CYP3A4CYP2D6CYP2C19TSHRBCL2 | |
| SCHEMBL5879437 | 0.74 | LMNA (0.40) | TSHRALDH1A1GLAL3MBTL1 | |
| SCHEMBL31438264 | 0.73 | ALDH1A1 (0.48) | CYP2D6TSHRCHRM2ALDH1A1GLA | |
| SCHEMBL7049331 | 0.73 | ALDH1A1 (0.48) | CYP2D6TSHRCHRM2ALDH1A1GLA | |
| SCHEMBL28335494 | 0.73 | ALDH1A1 (0.48) | CYP2D6TSHRCHRM2ALDH1A1GLA | |
| SCHEMBL4958841 | 0.72 | TP53 (0.37) | ALDH1A1MEN1KMT2ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115243764-B | Heterocyclic derivatives as TRMP antagonists | 奇华顿股份有限公司 | 2025-01-03 | — | — | CN | disclosed |
| EP-4114523-A1 | HETEROCYCLIC DERIVATIVES AS TRMP8 ANTAGONISTS | Givaudan SA (CH) | 2023-01-11 | — | — | EP | disclosed |
| CN-115243764-A | Heterocyclic derivatives as TRMP8 antagonists | 奇华顿股份有限公司 | 2022-10-25 | — | — | CN | disclosed |