Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | EED | O75530 | 1/20 | 0.39 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.39 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29939637 | 0.89 | TGFBR1 (0.41) | PDE2ATGFBR1JAK2JAK3IDO1 | |
| SCHEMBL30988101 | 0.87 | ELANE (0.40) | PDE2ATGFBR1IDO1KDM4EALDH1A1 | |
| SCHEMBL29939624 | 0.86 | DHODH (0.43) | PDE2AJAK2JAK3PTK2IRAK4 | |
| SCHEMBL29939563 | 0.84 | JAK2 (0.47) | PDE2ATGFBR1JAK2JAK3IDO1 | |
| SCHEMBL29939370 | 0.82 | SLC34A1 (0.45) | PDE2ATGFBR1JAK2JAK3IDO1 | |
| SCHEMBL29939402 | 0.82 | TGFBR1 (0.41) | PDE2ATGFBR1JAK2JAK3IDO1 | |
| SCHEMBL30029164 | 0.81 | PRKCZ (0.49) | PDE2AEEDTGFBR1JAK2JAK3 | |
| SCHEMBL30028340 | 0.81 | PDE2A (0.47) | PDE2AEEDTGFBR1KDM4EALDH1A1 | |
| SCHEMBL23013599 | 0.81 | PDE2A (0.41) | PDE2ATGFBR1IDO1KDM4EALDH1A1 | |
| SCHEMBL29939592 | 0.80 | ALDH1A1 (0.40) | PDE2ATGFBR1JAK2JAK3IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634425-B2 | Pharmaceutical compounds | PFIZER INC. (US) | 2023-04-25 | — | — | US | disclosed |
| US-20220324873-A1 | PHARMACEUTICAL COMPOUNDS | PFIZER INC. | 2022-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11634425-B2 | Pharmaceutical compounds | GABRA6, CHRNA6, CNR1 | PDE2A 4484/4885EED 2255/4885SUZ12 1681/4885 |
| US-20220324873-A1 | PHARMACEUTICAL COMPOUNDS | GABRA6, CNR1, CHRNA6 | PDE2A 4480/4885EED 2407/4885SUZ12 1442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.