Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.36 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5183 | 0.79 | HTR7 (0.51) | HTR7MAOBTRPV3 | |
| SCHEMBL29574709 | 0.79 | HTR7 (0.51) | HTR7MAOBTRPV3 | |
| SCHEMBL24321907 | 0.79 | KDM5A (0.41) | HTR7KDM5AKDM4CKDM5B | |
| SCHEMBL8726267 | 0.78 | MAOB (0.51) | HTR7MAOBMEN1KMT2ALMNA | |
| SCHEMBL30493343 | 0.77 | KDM5A (0.40) | MRGPRX4TRPV6KDM5AKDM4CKDM5B | |
| SCHEMBL23286947 | 0.75 | MAOB (0.48) | HTR7MRGPRX4MAOBKMT2A | |
| SCHEMBL29737927 | 0.75 | MAOB (0.49) | HTR7MAOBCYP3A4 | |
| SCHEMBL23286880 | 0.75 | MAOB (0.49) | HTR7MAOBCYP3A4 | |
| SCHEMBL9598308 | 0.74 | RAB9A (0.48) | HTR7MRGPRX4MAOB | |
| SCHEMBL22391931 | 0.72 | HTR7 (0.42) | HTR7MAOBMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4271672-A1 | CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-11-08 | — | — | EP | disclosed |
| WO-2022225941-A1 | CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-10-27 | — | — | WO | disclosed |