Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Iobenguane I 123. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.81 |
| ▸ | HTR1A | P08908 | 1/20 | 0.81 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.81 |
| ▸ | MAOA | P21397 | 1/20 | 0.81 |
| ▸ | DRD1 | P21728 | 1/20 | 0.81 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.81 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.81 |
| ▸ | DRD3 | P35462 | 1/20 | 0.81 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.81 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.66 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.59 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.59 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.59 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.59 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.59 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iobenguane I 123 SCHEMBL29381016 | 0.90 | HTR1A (1.00) | HTR1AADRA2AMAOADRD1SLC6A2 | |
| Iobenguane SCHEMBL9798689 | 0.79 | SMN1; SMN2 (1.00) | HTR1AADRA2AMAOADRD1SLC6A2 | |
| Iobenguane SCHEMBL29435410 | 0.79 | SMN1; SMN2 (1.00) | HTR1AADRA2AMAOADRD1SLC6A2 | |
| Iobenguane SCHEMBL29722658 | 0.79 | SMN1; SMN2 (1.00) | HTR1AADRA2AMAOADRD1SLC6A2 | |
| Sulfuric Acid SCHEMBL4014387 | 0.78 | LMNA (0.65) | HTR1AADRA2AMAOADRD1SLC6A2 | |
| Hydrochloric Acid SCHEMBL538276 | 0.73 | HTR3E (0.96) | HTR1AADRA2AMAOADRD1SLC6A2 | |
| M-Fluorobenzylguanidine SCHEMBL11882096 | 0.73 | TAAR1 (0.60) | HTR1AADRA2AMAOADRD1SLC6A2 | |
| Iobenguane I 123 SCHEMBL29351173 | 0.71 | HTR1A (0.44) | HTR1AADRA2AMAOADRD1SLC6A2 | |
| SCHEMBL23521033 | 0.71 | GRIN2B (0.74) | HTR1AADRA2AMAOADRD1SLC6A2 | |
| SCHEMBL15903395 | 0.69 | TAAR1 (0.73) | HTR1AADRA2AMAOADRD1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250345629-A1 | JOINT OPTIMIZATION OF RADIONUCLIDE AND EXTERNAL BEAM RADIOTHERAPY | REFLEXION MEDICAL INC (US) | 2025-11-13 | — | — | US | disclosed |
| US-12268895-B2 | Joint optimization of radionuclide and external beam radiotherapy | REFLEXION MEDICAL, INC. (US) | 2025-04-08 | — | — | US | disclosed |
| US-20230405359-A1 | JOINT OPTIMIZATION OF RADIONUCLIDE AND EXTERNAL BEAM RADIOTHERAPY | REFLEXION MEDICAL, INC. | 2023-12-21 | — | — | US | disclosed |
| US-11654300-B2 | Joint optimization of radionuclide and external beam radiotherapy | REFLEXION MEDICAL, INC. (US) | 2023-05-23 | — | — | US | disclosed |
| CN-115279456-A | Combined optimization of radionuclides and external beam radiotherapy | 反射医疗公司 | 2022-11-01 | — | — | CN | disclosed |