Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.44 |
| ▸ | GABRD | O14764 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23539672 | 1.00 | VCP (0.55) | VCPNPC1TP53TSHRNFKB1 | |
| SCHEMBL17129773 | 0.82 | MAP4K4 (0.51) | NPC1RAB9A | |
| SCHEMBL26307287 | 0.82 | FLT1 (0.49) | VCPNPC1TP53TSHRRAB9A | |
| SCHEMBL5186343 | 0.82 | HSD17B1 (0.58) | VCPTP53SMN1; SMN2GABRPGABRD | |
| SCHEMBL9954595 | 0.82 | GABRP (0.46) | VCPFFAR1GABRPGABRDGABRA1 | |
| SCHEMBL1544316 | 0.82 | VCP (0.52) | VCPNPC1TP53TSHRNFKB1 | |
| SCHEMBL31557485 | 0.82 | VCP (0.52) | VCPNPC1TP53TSHRNFKB1 | |
| SCHEMBL20243152 | 0.82 | VCP (0.52) | VCPNPC1TP53TSHRNFKB1 | |
| SCHEMBL29231690 | 0.81 | TSHR (0.66) | VCPNPC1TP53TSHRNFKB1 | |
| SCHEMBL1363021 | 0.80 | ALOX15 (0.59) | VCPNPC1TP53TSHRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115279741-A | 4-phenyl-N- (phenyl) thiazol-2-amine derivatives and related compounds as Aryl Hydrocarbon Receptor (AHR) agonists for the treatment of, for example, angiogenesis-related disorders or inflammatory disorders | 医肯纳肿瘤学公司 | 2022-11-01 | — | — | CN | disclosed |