Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | ATF1 | P18846 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | STK17B | O94768 | 1/20 | 0.30 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26260575 | 1.00 | HDAC1 (0.37) | HDAC1HDAC8HDAC6SOS1ATF1 | |
| SCHEMBL30060442 | 0.78 | KCNQ4 (0.35) | HDAC1HDAC8HDAC6SOS1CACNA1G | |
| SCHEMBL23611364 | 0.77 | ALDH1A1 (0.37) | HDAC1HDAC8HDAC6SOS1NFKB1 | |
| SCHEMBL30060460 | 0.77 | ALDH1A1 (0.37) | HDAC1HDAC8HDAC6SOS1NFKB1 | |
| SCHEMBL31168452 | 0.75 | PAX8 (0.39) | SOS1ATF1NFKB1CACNA1GCACNA1B | |
| SCHEMBL3065683 | 0.68 | BCL2A1 (0.42) | HDAC1HDAC8HDAC6 | |
| SCHEMBL12675381 | 0.67 | KCNH2 (0.40) | HDAC1HDAC8HDAC6SSTR4SCN9A | |
| SCHEMBL30763505 | 0.67 | HDAC1 (0.41) | HDAC1HDAC8HDAC6SOS1CACNA1G | |
| SCHEMBL30763497 | 0.67 | HDAC1 (0.49) | HDAC1HDAC8HDAC6SOS1SSTR4 | |
| SCHEMBL6081384 | 0.67 | MAPK14 (0.43) | HDAC1HDAC8HDAC6SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4085054-B1 | NEW PQSR INVERSE AGONISTS | HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) | 2025-02-19 | — | — | EP | disclosed |
| US-20230286942-A1 | NEW PqsR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2023-09-14 | — | — | US | disclosed |
| EP-4085054-A1 | NEW PQSR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2022-11-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230286942-A1 | NEW PqsR INVERSE AGONISTS | QRFPR, P2RY11, GPR55 | HDAC1 3860/4885HDAC8 4392/4885HDAC6 2052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.