Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.36 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BID | P55957 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30060460 | 1.00 | ALDH1A1 (0.37) | ALDH1A1MAPK1L3MBTL1P2RX3HPGD | |
| SCHEMBL30060442 | 0.81 | KCNQ4 (0.35) | SOS1HDAC1HDAC8HDAC6 | |
| SCHEMBL23611521 | 0.79 | ALDH1A1 (0.35) | ALDH1A1MAPK1L3MBTL1P2RX3HPGD | |
| SCHEMBL31168452 | 0.78 | PAX8 (0.39) | KMT2AKDM4EMEN1SOS1NFKB1 | |
| SCHEMBL5906809 | 0.78 | P2RX3 (0.43) | ALDH1A1L3MBTL1P2RX3KMT2ALMNA | |
| SCHEMBL26260575 | 0.77 | HDAC1 (0.37) | SOS1NFKB1HDAC1HDAC8HDAC6 | |
| SCHEMBL30041593 | 0.77 | HDAC1 (0.37) | SOS1NFKB1HDAC1HDAC8HDAC6 | |
| SCHEMBL25213314 | 0.74 | CYP3A4 (0.43) | ALDH1A1P2RX3KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL13247764 | 0.74 | L3MBTL1 (0.37) | ALDH1A1MAPK1L3MBTL1P2RX3KMT2A | |
| SCHEMBL6213093 | 0.72 | F2 (0.44) | ALDH1A1MAPK1P2RX3HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4085057-B1 | PYRIDINE AND PYRIMIDINE DERIVATIVES USEFUL AS PQSR INVERSE AGONISTS | HELMHOLTZ ZENTRUM INFEKTIONSFORSCHUNG GMBH (DE) | 2025-10-08 | — | — | EP | disclosed |
| US-20230106506-A1 | NOVEL PqsR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2023-04-06 | — | — | US | disclosed |
| EP-4085057-A1 | NOVEL PQSR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2022-11-09 | — | — | EP | disclosed |
| WO-2021136805-A1 | NOVEL PqsR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2021-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230106506-A1 | NOVEL PqsR INVERSE AGONISTS | QRFPR, P2RY11, GPR55 | ALDH1A1 4630/4885MAPK1 887/4885L3MBTL1 4496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.