Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20320551 | 0.83 | SLC6A2 (0.35) | SMN1; SMN2KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24072578 | 0.79 | OPRM1 (0.36) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10217176 | 0.73 | CA2 (0.39) | SMN1; SMN2ALDH1A1EPHX2USP2 | |
| SCHEMBL16590521 | 0.72 | SLC6A2 (0.38) | SMN1; SMN2KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20320549 | 0.71 | SLC6A2 (0.40) | SMN1; SMN2KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1918290 | 0.71 | SLC6A2 (0.37) | SMN1; SMN2KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12154570 | 0.71 | ALDH1A1 (0.37) | SMN1; SMN2KMT2AALDH1A1GAAEPHX2 | |
| SCHEMBL24072577 | 0.69 | TRPM8 (0.38) | SMN1; SMN2KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15324070 | 0.69 | KMT2A (0.40) | SMN1; SMN2KMT2AALDH1A1EGFRGAA | |
| SCHEMBL12310471 | 0.68 | TRPM8 (0.37) | SMN1; SMN2KMT2ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359415-A1 | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2024-05-01 | — | — | EP | disclosed |
| WO-2022271684-A1 | DIACYLGLYERCOL KINASE MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-12-29 | — | — | WO | disclosed |