Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.35 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30051419 | 0.89 | GRM5 (0.40) | GRM5ALDH1A1SMN1; SMN2PKMMAPT | |
| SCHEMBL24569747 | 0.84 | KMT2A (0.43) | ALDH1A1SMN1; SMN2PKMMAPTLMNA | |
| SCHEMBL30049938 | 0.83 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2PKMMAPTLMNA | |
| SCHEMBL30050598 | 0.82 | GRM5 (0.39) | GRM5ALDH1A1SMN1; SMN2PKMMAPT | |
| SCHEMBL24807701 | 0.81 | GRM5 (0.42) | GRM5DOT1LBRAF | |
| SCHEMBL30050420 | 0.81 | GRM5 (0.42) | GRM5DOT1LBRAF | |
| SCHEMBL30050656 | 0.80 | L3MBTL1 (0.46) | GRM5ALDH1A1SMN1; SMN2PKMMAPT | |
| SCHEMBL29197501 | 0.79 | GRM5 (0.38) | GRM5ALDH1A1MAPTLMNAHTT | |
| SCHEMBL29197364 | 0.79 | GRM5 (0.38) | GRM5ALDH1A1SMN1; SMN2PKMMAPT | |
| SCHEMBL30051353 | 0.78 | GRM5 (0.40) | GRM5ALDH1A1SMN1; SMN2PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022269531-A1 | HER2 MUTATION INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2022-12-29 | — | — | WO | disclosed |