Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | CTSV | O60911 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300360 | 0.91 | CNR2 (0.46) | CNR2MAPK1FKBP1A | |
| SCHEMBL300469 | 0.88 | CYP3A4 (0.40) | CNR2MAPK1FKBP1A | |
| SCHEMBL176767 | 0.87 | CNR2 (0.54) | CNR2MAPK1PTGER4TRPV4 | |
| SCHEMBL176441 | 0.87 | CNR2 (0.54) | CNR2MAPK1PTGER4TRPV4 | |
| SCHEMBL300688 | 0.81 | CNR2 (0.39) | CNR2 | |
| SCHEMBL176606 | 0.79 | MAPK1 (0.45) | CNR2MAPK1PTGER4TRPV4PDE1B | |
| SCHEMBL176628 | 0.79 | MAPK1 (0.45) | CNR2MAPK1PTGER4TRPV4PDE1B | |
| SCHEMBL300504 | 0.78 | CNR2 (0.42) | CNR2 | |
| SCHEMBL3466374 | 0.78 | CNR2 (0.46) | CNR2 | |
| SCHEMBL300521 | 0.78 | CNR2 (0.43) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937259-B1 | HEXAHYDRO-CYCLOHEPTAPYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-11-23 | — | — | EP | claimed |