Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23702440 | 1.00 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL26424078 | 0.84 | LMNA (0.46) | MAPTLMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL22588438 | 0.82 | KDM4E (0.46) | MAPTLMNAPOLBHPGDNPSR1 | |
| SCHEMBL22594436 | 0.80 | ALDH1A1 (0.40) | MAPTCYP2C19KDM4EALDH1A1 | |
| SCHEMBL22588114 | 0.79 | LDHA (0.47) | MAPTLMNAALDH1A1KMT2A | |
| SCHEMBL19281442 | 0.79 | PTPN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22602039 | 0.79 | LDHA (0.35) | MAPTSCN9ANPC1 | |
| SCHEMBL29689706 | 0.79 | LDHA (0.47) | MAPTLMNAALDH1A1KMT2A | |
| SCHEMBL29689630 | 0.79 | LDHA (0.35) | MAPTSCN9ANPC1 | |
| SCHEMBL29241829 | 0.79 | ATF4 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4117780-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | Evotec International GmbH (DE) | 2023-01-18 | — | — | EP | disclosed |
| EP-4096665-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | Evotec International GmbH (DE) | 2022-12-07 | — | — | EP | disclosed |