Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049129 | 0.88 | TP53 (0.42) | TP53MAPTKDM4EGLALMNA | |
| SCHEMBL27796461 | 0.86 | CSNK2A1 (0.47) | TP53MAPTPIK3CDPIK3CBPIK3CG | |
| SCHEMBL28299564 | 0.83 | GRM5 (0.38) | MAPTKDM4EPIK3CAALDH1A1GAA | |
| SCHEMBL300845 | 0.72 | THRB (0.49) | THRBTP53MAPTKDM4EGLA | |
| SCHEMBL300899 | 0.70 | CSNK2A1 (0.41) | MAPTKDM4ELMNAALDH1A1HPGD | |
| SCHEMBL301294 | 0.70 | KDM4E (0.43) | MAPTKDM4EGLALMNAALDH1A1 | |
| SCHEMBL5035054 | 0.69 | DHPS (0.51) | THRBPIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL300925 | 0.68 | PIK3CD (0.70) | TP53MAPTKDM4EGLAPIK3CD | |
| SCHEMBL300813 | 0.67 | KDM4E (0.74) | TP53MAPTKDM4EGLAPIK3CD | |
| SCHEMBL28901024 | 0.66 | KDM4E (0.58) | TP53MAPTKDM4EGLAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2012-03-14 | — | — | EP | claimed |
| CN-109846884-A | With TOR kinase inhibitor for treating cancer | 西格诺药品有限公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-104271139-A | Treatment of cancer with tor kinase inhibitors | SIGNAL PHARM LLC | 2015-01-07 | — | — | CN | disclosed |
| CN-104271138-A | Treatment of cancer with tor kinase inhibitors | SIGNAL PHARM LLC | 2015-01-07 | — | — | CN | disclosed |
| CN-102821767-A | IDENTIFICATION OF LKB1 MUTATION AS A PREDICTIVE BIOMARKER FOR SENSITIVITY TO TOR KINASE INHIBITORS | SIGNAL PHARM LLC | 2012-12-12 | — | — | CN | disclosed |