Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27796479 | 0.83 | XDH (0.53) | TP53MAPTLMNAPIK3CDPIK3CB | |
| SCHEMBL300887 | 0.83 | LMNA (0.51) | THRBKDM4EGLATP53MAPT | |
| SCHEMBL301187 | 0.82 | MAPK8 (0.41) | THRBTP53LMNATSHRMAPK1 | |
| SCHEMBL28142358 | 0.81 | CHKA (0.39) | KDM4ETP53MAPTLMNAALDH1A1 | |
| SCHEMBL5035054 | 0.72 | DHPS (0.51) | THRBPIK3CDPIK3CBPIK3CGPIK3CA | |
| SCHEMBL300902 | 0.72 | THRB (0.43) | THRBKDM4EGLATP53MAPT | |
| SCHEMBL300925 | 0.72 | PIK3CD (0.70) | KDM4EGLATP53MAPTLMNA | |
| SCHEMBL27879147 | 0.70 | XDH (0.53) | KDM4EMAPTLMNAALDH1A1GAA | |
| SCHEMBL27796448 | 0.69 | PIK3CD (0.71) | KDM4EGLATP53MAPTLMNA | |
| SCHEMBL297838 | 0.69 | KDM4E (0.60) | KDM4EGLATP53MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2012-03-14 | — | — | EP | claimed |
| CN-109846884-A | With TOR kinase inhibitor for treating cancer | 西格诺药品有限公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-108992446-A | With TOR kinase inhibitor for treating cancer | 西格诺药品有限公司 | 2018-12-14 | — | — | CN | disclosed |
| CN-104271159-B | The method that non-small cell lung cancer is treated using the therapeutic alliance of TOR kinase inhibitors | 西格诺药品有限公司 | 2017-11-28 | — | — | CN | disclosed |
| CN-107157990-A | Utilize TOR kinase inhibitor for treating cancers | 西格诺药品有限公司 | 2017-09-15 | — | — | CN | disclosed |
| CN-107137402-A | With TOR kinase inhibitor for treating cancers | 西格诺药品有限公司 | 2017-09-08 | — | — | CN | disclosed |
| CN-104302295-B | Treatment of cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2017-06-20 | — | — | CN | disclosed |
| CN-103998036-B | Treatment of cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-105050601-A | Treatment of prostate cancer with TOR kinase inhibitors | SIGNAL PHARM LLC | 2015-11-11 | — | — | CN | disclosed |
| CN-104519885-A | Treatment of cancer with TOR kinase inhibitors | SIGNAL PHARM LLC | 2015-04-15 | — | — | CN | disclosed |
| CN-104302295-A | Treatment of cancer with tor kinase inhibitors | SIGNAL PHARM LLC | 2015-01-21 | — | — | CN | disclosed |
| CN-104271139-A | Treatment of cancer with tor kinase inhibitors | SIGNAL PHARM LLC | 2015-01-07 | — | — | CN | disclosed |
| CN-104271159-A | Methods for treating non- small cell lung cancer using tor kinase inhibitor combination therapy | SIGNAL PHARM LLC | 2015-01-07 | — | — | CN | disclosed |
| CN-104271138-A | Treatment of cancer with tor kinase inhibitors | SIGNAL PHARM LLC | 2015-01-07 | — | — | CN | disclosed |
| CN-103998036-A | Treatment of cancer with TOR kinase inhibitors | SIGNAL PHARM LLC | 2014-08-20 | — | — | CN | disclosed |
| CN-102821767-A | IDENTIFICATION OF LKB1 MUTATION AS A PREDICTIVE BIOMARKER FOR SENSITIVITY TO TOR KINASE INHIBITORS | SIGNAL PHARM LLC | 2012-12-12 | — | — | CN | disclosed |
| EP-2078018-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051494-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |