Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 15/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29136680 | 1.00 | RIPK1 (0.46) | RIPK1 | |
| SCHEMBL22638823 | 0.90 | RIPK1 (0.51) | RIPK1 | |
| SCHEMBL22638820 | 0.90 | RIPK1 (0.51) | RIPK1 | |
| SCHEMBL22638907 | 0.90 | RIPK1 (0.51) | RIPK1 | |
| Hydrochloric Acid SCHEMBL28931982 | 0.88 | RIPK1 (0.50) | RIPK1 | |
| Trifluoroacetic Acid SCHEMBL28619776 | 0.80 | RIPK1 (0.52) | RIPK1 | |
| SCHEMBL30090447 | 0.78 | CYP2A6 (0.35) | RIPK1 | |
| SCHEMBL29136717 | 0.78 | CYP2A6 (0.35) | RIPK1 | |
| SCHEMBL28938984 | 0.78 | ALDH1A1 (0.43) | RIPK1 | |
| SCHEMBL28629177 | 0.78 | RIPK1 (0.55) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4341247-A1 | RIP1 MODULATORS INCLUDING AZETIDINE CYCLIC UREAS, PREPARATIONS, AND USES THEREOF | Sironax Ltd (KY) | 2024-03-27 | — | — | EP | disclosed |
| CN-117355506-A | RIP1 modulators comprising azetidine cyclic ureas, preparation and use thereof | 维泰瑞隆有限公司 | 2024-01-05 | — | — | CN | disclosed |
| WO-2022242581-A1 | RIP1 MODULATORS INCLUDING AZETIDINE CYCLIC UREAS, PREPARATIONS, AND USES THEREOF | Sironax Ltd. (KY) | 2022-11-24 | — | — | WO | disclosed |