Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RAD52 | P43351 | 2/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | TERT | O14746 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL452116 | 1.00 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL451943 | 1.00 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL448359 | 1.00 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL449176 | 1.00 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL29935401 | 0.99 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL452379 | 0.95 | TERT (0.46) | NPC1RAB9ASMN1; SMN2HTTKDM4E | |
| SCHEMBL450264 | 0.89 | TERT (0.48) | TERT | |
| SCHEMBL30096018 | 0.85 | TERT (0.41) | SMN1; SMN2HTTKDM4ELMNATERT | |
| SCHEMBL16934676 | 0.85 | TERT (0.41) | SMN1; SMN2HTTKDM4ELMNATERT | |
| SCHEMBL453031 | 0.85 | TERT (0.52) | TERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308107-A1 | MNTBAP AND M(III)N-SUBSTITUTED PYRIDYLPORPHYRINS(MNPS)FOR USE IN REVERSING SEPSIS-INDUCED MICROGLIAL CELLS ALTERATIONS AND/OR FOR TREATING SEPSIS OR SEPSIS-ASSOCIATED ENCEPHALOPATHY | INSTITUT PASTEUR (FR) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022195100-A1 | MNTBAP AND M(III)N-SUBSTITUTED PYRIDYLPORPHYRINS(MNPS)FOR USE IN REVERSING SEPSIS-INDUCED MICROGLIAL CELLS ALTERATIONS AND/OR FOR TREATING SEPSIS OR SEPSIS-ASSOCIATED ENCEPHALOPATHY | INSTITUT PASTEUR (FR) | 2022-09-22 | — | — | WO | disclosed |