Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | RAD52 | P43351 | 2/20 | 0.38 |
| ▸ | RGS12 | O14924 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL449176 | 0.95 | NPC1 (0.45) | TERTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL452116 | 0.95 | NPC1 (0.45) | TERTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL448359 | 0.95 | NPC1 (0.45) | TERTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL30096016 | 0.95 | NPC1 (0.45) | TERTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL451943 | 0.95 | NPC1 (0.45) | TERTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL29935401 | 0.94 | NPC1 (0.44) | TERTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL450264 | 0.92 | TERT (0.48) | TERTTOP1 | |
| SCHEMBL30096018 | 0.88 | TERT (0.41) | TERTSMN1; SMN2KDM4EHTTLMNA | |
| SCHEMBL16934676 | 0.88 | TERT (0.41) | TERTSMN1; SMN2KDM4EHTTLMNA | |
| SCHEMBL453031 | 0.87 | TERT (0.52) | TERTTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065181-A1 | METHOD OF PROVIDING NEUROPROTECTION USING SUBSTITUTED PORPHYRINS | DUKE UNIVERSITY | 2012-03-15 | — | — | US | disclosed |
| US-20080113956-A1 | Substituted Porphyrins | FRIDOVICH IRWIN | 2008-05-15 | — | — | US | disclosed |
| US-20070179124-A1 | Substituted Porphyrins | FRIDOVICH IRWIN | 2007-08-02 | — | — | US | disclosed |
| US-20060074062-A1 | Substituted porphyrins | DUKE UNIVERSITY (US) | 2006-04-06 | — | — | US | disclosed |
| US-6916799-B2 | Substituted porphyrins | DUKE UNIVERSITY (US) | 2005-07-12 | — | — | US | disclosed |
| EP-1045851-B1 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2003-04-23 | — | — | EP | disclosed |
| US-20020042407-A1 | Antiinflammatory agents; respiratory system disorders | DUKE UNIVERSITY | 2002-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113956-A1 | Substituted Porphyrins | PPOX, GPX4, PRDX5 | TERT 821/4885NPC1 1702/4885RAB9A 3264/4885 |
| US-20070179124-A1 | Substituted Porphyrins | PPOX, GPX4, PRDX5 | TERT 821/4885NPC1 1702/4885RAB9A 3264/4885 |
| US-20120065181-A1 | METHOD OF PROVIDING NEUROPROTECTION USING SUBSTITUTED PORPHYRINS | SOD1, PYGB, PSAP | TERT 4141/4885NPC1 955/4885RAB9A 3499/4885 |
| US-20020042407-A1 | Antiinflammatory agents; respiratory system disorders | LPO, PRDX5, MPO | TERT 3237/4885NPC1 4094/4885RAB9A 3881/4885 |
| US-20060074062-A1 | Substituted porphyrins | PPOX, GPX4, PRDX5 | TERT 821/4885NPC1 1702/4885RAB9A 3264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.