SCHEMBL30097048

SCHEMBL30097048

CCCCOC(=O)NCc1cc2c(cn1)CCN(c1ccccc1OC)C2

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.41
MAPT P10636 1/20 0.41
DRD2 P14416 10/20 0.40
DRD3 P35462 4/20 0.40
KDM4E B2RXH2 2/20 0.40
ADRA1D P25100 1/20 0.40
ADRA1A P35348 1/20 0.40
ADRA1B P35368 1/20 0.40
HSD17B10 Q99714 1/20 0.40
DRD4 P21917 2/20 0.40
HTR1A P08908 2/20 0.39
HTR2A P28223 1/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A4 P31645 1/20 0.39
ALDH1A1 P00352 1/20 0.39
TDP1 Q9NUW8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23706197 0.85 DRD2 (0.43) MAPTDRD2DRD3ADRA1ADRD4
SCHEMBL26144124 0.85 DRD2 (0.53) MAPTDRD2DRD3ADRA1ADRD4
SCHEMBL26141777 0.76 MAPT (0.47) TP53MAPTDRD2DRD3DRD4
Hydrochloric Acid SCHEMBL30042364 0.75 MAPT (0.46) TP53MAPTDRD2DRD3DRD4
Hydrochloric Acid SCHEMBL23706020 0.75 MAPT (0.46) TP53MAPTDRD2DRD3DRD4
SCHEMBL30097038 0.72 L3MBTL1 (0.38)
SCHEMBL23706101 0.71 DRD2 (0.39) TP53MAPTDRD2DRD3ADRA1D
SCHEMBL23706103 0.71 DRD2 (0.39) TP53MAPTDRD2DRD3ADRA1D
SCHEMBL30041995 0.71 DRD2 (0.39) TP53MAPTDRD2DRD3ADRA1D
SCHEMBL30097024 0.71 GAA (0.38) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4096667-A1 COMPOUNDS AND USES THEREOF Foghorn Therapeutics Inc. (US) 2022-12-07 EP disclosed