Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | XBP1 | P17861 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.68 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.68 |
| ▸ | ATM | Q13315 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3160763 | 1.00 | MAPT (0.68) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL3262089 | 0.81 | MAPT (1.00) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL29516939 | 0.81 | MAPT (1.00) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL13295325 | 0.81 | MAPT (0.56) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL11453080 | 0.79 | LMNA (0.65) | ALDH1A1NPSR1LMNAATMKMT2A | |
| SCHEMBL30583271 | 0.78 | ALDH1A1 (0.67) | MAPTALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL5001108 | 0.78 | ALDH1A1 (0.67) | MAPTALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL11455384 | 0.77 | MAPT (0.46) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL11445281 | 0.77 | MAPT (0.47) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL30541541 | 0.77 | FEN1 (0.50) | MAPTALDH1A1NPSR1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115103841-B | Substituted quinolinone piperazine compounds useful as T cell activators | 百时美施贵宝公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-115103841-A | Substituted quinolinonyl piperazine compounds useful as T cell activators | 百时美施贵宝公司 | 2022-09-23 | — | — | CN | disclosed |